ArticleWorm2014
From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system.
Article in Worm, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans.PLoS genetics · 2022Article
- The left-right side-specific endocrine signaling in the effects of brain lesions: questioning of the neurological dogma.Cellular and molecular life sciences : CMLS · 2022Review
- Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling.Translational psychiatry · 2018Article
- Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuropeptide signaling remodels the composition of a chemosensory circuit and shapes behavior in Caenorhabditis elegans. We reported that the ASE left (ASEL) salt sensory neuron uses a proprotein convertase, BLI-4, to cleave the insulin-like peptide INS-6. INS-6 peptides are released from the ASEL neuron in response to large, but not small changes in salt stimuli. Fast INS-6 signaling functionally transforms the AWC olfactory sensory neuron into an interneuron in the neural circuit for high salt. This new circuit configuration potentiates behavioral attraction to high salt. Here, in the context of genes, circuits, and behaviors, we discuss the diverse modes of neuropeptide processing and signaling, which expand the coding potential of the nervous system. First, neuropeptide processing and release genes prepare insulin peptides to signal in the nervous system. Second, this neuropeptide signaling diversifies the communication of neural circuits and introduces circuit-level flexibility. Finally, the resulting multisensory neurons and circuits drive finely tuned behavioral choices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.