Evidence map›Paper›PMID 25254116›Full record

ArticleJournal of pregnancy2014

Maternal opioid drug use during pregnancy and its impact on perinatal morbidity, mortality, and the costs of medical care in the United States.

Valerie E Whiteman, Jason L Salemi, Mulubrhan F Mogos, Mary Ashley Cain, Muktar H Aliyu, Hamisu M Salihu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pregnancy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 4 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 172 citations in OpenAlex.

  1. Pooled it
  2. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2022
    Guideline
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Valerie E WhitemanDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA.
Jason L SalemiMaternal and Child Health Comparative Effectiveness Research Group, Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs Boulevard MDC 56, Tampa, FL 33612, USA.
Mulubrhan F MogosDepartment of Community and Health Systems, School of Nursing, University of Indiana, 1111 Middle Drive, Indianapolis, IN 46202, USA.
Mary Ashley CainDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA.
Muktar H AliyuDepartment of Health Policy and Medicine, Vanderbilt University, 2525 West End Avenue, Suite 750, Nashville, TN 32703, USA.
Hamisu M SalihuDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA ; Maternal and Child Health Comparative Effectiveness Research Group, Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs Boulevard MDC 56, Tampa, FL 33612, USA.
University of South Florida · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify factors associated with opioid use during pregnancy and to compare perinatal morbidity, mortality, and healthcare costs between opioid users and nonusers.

methodsWe conducted a cross-sectional analysis of pregnancy-related discharges from 1998 to 2009 using the largest publicly available all-payer inpatient database in the United States. We scanned ICD-9-CM codes for opioid use and perinatal outcomes. Costs of care were estimated from hospital charges. Survey logistic regression was used to assess the association between maternal opioid use and each outcome; generalized linear modeling was used to compare hospitalization costs by opioid use status.

resultsWomen who used opioids during pregnancy experienced higher rates of depression, anxiety, and chronic medical conditions. After adjusting for confounders, opioid use was associated with increased odds of threatened preterm labor, early onset delivery, poor fetal growth, and stillbirth. Users were four times as likely to have a prolonged hospital stay and were almost four times more likely to die before discharge. The mean per-hospitalization cost of a woman who used opioids during pregnancy was $5,616 (95% CI: $5,166-$6,067), compared to $4,084 (95% CI: $4,002-$4,166) for nonusers.

conclusionOpioid use during pregnancy is associated with adverse perinatal outcomes and increased healthcare costs.

Indexed as

Perinatal MortalityAdolescentAdultAnalgesics, OpioidCross-Sectional StudiesFemaleHealth Care CostsHumansInfant, NewbornInfant, Newborn, DiseasesObstetric Labor, PrematurePregnancyPregnancy ComplicationsPregnancy OutcomeStillbirthUnited StatesAnalgesics, Opioid

Identifiers

PMID25254116
PMCPMC4164310
OpenAlexW2061327077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.