ReviewJournal of ophthalmology2014
Genetics of keratoconus: where do we stand?
Review in Journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Pooled it
- The effects of green tea tablets and metformin on ovulation and menstrual cycle regularity in women with polycystic ovary syndrome.Journal of medicine and life · 2024Trial
- Evaluation of the Physiological Corneal Intrastromal Riboflavin Concentration and the Corneal Elastic Modulus After Violet Light Irradiation.Translational vision science & technology · 2021Trial
- Association between attention deficit hyperactivity disorder and keratoconus.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2026Article
- Analysis of Keratoconus-Related Phenotypes in Two Pcsk1 Mouse Models.Translational vision science & technology · 2026Article
- Proteomic Analysis Provides Insights Into PPIP5K2 Function and Its Impact on Corneal Energy Metabolism.Investigative ophthalmology & visual science · 2025Article
- Understanding Keratoconus in Down Syndrome: From Etiology to Management - A Narrative Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Role of epigenetics in corneal health and disease.Progress in retinal and eye research · 2025Review
- Computational approaches for identifications of altered ion channels in keratoconus.Eye (London, England) · 2025Article
- Tear proteomic analysis in keratoconus patients and potential biomarkers: a case-control study.Experimental biology and medicine (Maywood, N.J.) · 2025Observational
- Keratoconus.Nature reviews. Disease primers · 2024Article
- Identification of Keratoconus-Related Phenotypes in Three Ppip5k2 Mouse Models.Investigative ophthalmology & visual science · 2024Article
- Balanced activation of Nrf-2/ARE mediates the protective effect of sulforaphane on keratoconus in the cell mechanical microenvironment.Scientific reports · 2024Article
- AvaGen Genetic Testing versus Ocular Screening Assessments Including the Keratoconus Severity Score (KSS) and Randleman Ectasia Risk Score System (ERSS) in Refractive Surgery Candidates.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Association between Polymorphism rs61876744 inGenes · 2023Article
- Systemic Associations with Keratoconus.Life (Basel, Switzerland) · 2023Review
- Bowman Layer Transplantation for Treating Keratoconus-Preliminary Findings.Journal of clinical medicine · 2023Review
- Low-intensity low-frequency ultrasound mediates riboflavin delivery during corneal crosslinking.Bioengineering & translational medicine · 2023Article
- Mitochondrial DNA heteroplasmy analysis in keratoconus patients from China.Frontiers in genetics · 2023Article
- Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets.Progress in retinal and eye research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratoconus is a progressive thinning and anterior protrusion of the cornea that results in steepening and distortion of the cornea, altered refractive powers, and reduced vision. Keratoconus has a complex multifactorial etiology, with environmental, behavioral, and multiple genetic components contributing to the disease pathophysiology. Using genome-wide and candidate gene approaches several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. The review focuses on current knowledge of these genetic risk factors associated with keratoconus.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.