Evidence map›Paper›PMID 25254075›Full record

ArticleMolecular cytogenetics2014

An adult B-cell precursor acute lymphoblastic leukemia with multiple secondary cytogenetic aberrations.

Walid Al-Achkar, Abdulsamad Wafa, Moneeb Abdullah Kassem Othman, Faten Moassass, Abdulmunim Aljapawe, Thomas Liehr

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cytogenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Walid Al-AchkarDepartment of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
Abdulsamad WafaDepartment of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
Moneeb Abdullah Kassem OthmanInstitute of Human Genetics, Jena University Hospital, Jena, Germany.
Faten MoassassDepartment of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
Abdulmunim AljapaweDepartment of Molecular Biology and Biotechnology, Mammalians Biology Division, Atomic Energy Commission, Damascus, Syria.
Thomas LiehrInstitute of Human Genetics, Jena University Hospital, Jena, Germany.
Atomic Energy Commission of Syria · SYJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe report a clinically diagnosed acute lymphoblastic leukemia (ALL) with yet unreported secondary chromosomal aberrations.

resultsA complete cytogenetic and molecular cytogenetic analysis, using GTG banding, fluorescence in situ hybridization (FISH) and array-proven multicolor banding (aMCB), for a female patient with clinically diagnosed ALL and immunophenotypically confirmed pre-B ALL (FAB classifications), revealed the presence of a complex structural rearrangement, der (2) (20qter- > 20q13.33::2q21- > 2p14::2q21 > 2qter) along with t (9;22) (q34;q11), t (12;14) (q12;p12) and a monosomy of chromosome 7.

conclusionsMolecular cytogenetic studies are suited best for identification and characterization of chromosomal rearrangements in acute leukemia. Single case reports as well as large scale studies are necessary to provide further insights in karyotypic changes taking place in human malignancies.

Indexed as

Acute lymphoblastic leukemiaArray-proven multicolor bandingFluorescence in situ hybridizationPhiladelphia chromosomePrognostic factorsSecondary chromosomal abnormalities

Identifiers

PMID25254075
PMCPMC4172788
OpenAlexW2154609997

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