Evidence map›Paper›PMID 25254011›Full record

ReviewPostepy dermatologii i alergologii2014

Interleukin-17 in human inflammatory diseases.

Arezoo Gowhari Shabgah, Ebrahim Fattahi, Fatemeh Zare Shahneh

Open access · goldAbstract readReview
In one paragraph

Review in Postepy dermatologii i alergologii, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 169 citations in OpenAlex.

  1. Trial
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  7. Review
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  11. Profiling Genome-Wide Methylation Patterns in Cattle Infected withInternational journal of molecular sciences · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Interleukins: pathophysiological role in acute pancreatitis.Archives of medical science : AMS · 2024
    Article
  17. The IL-17 family in diseases: from bench to bedside.Signal transduction and targeted therapy · 2023
    Review
  18. Conundrum for Psoriasis and Thyroid Involvement.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arezoo Gowhari ShabgahDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Head of Department: Prof. Abbas Mirshafiey.
Ebrahim FattahiDepartment of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran. Head of Department: Dr. Jafar Majidi.
Fatemeh Zare ShahnehMultiphase Chemistry Departments, Max Planck Institute for Chemistry, Mainz, Germany. Head of Department: Prof. Dr. Detlef Schuppan ; Division of Translational Immunology, Department of Medicine I, University Medical Center, Johannes Gutenberg University, Mainz, Germany. Head of Department: Prof. Dr. Ulrich Pöschl.
Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The associated receptors for the IL-17 family identified are IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. This review introduces the roles of IL-17 and Th17 cells in human autoimmune diseases. Studies have shown that T cells with inflammatory effects on epithelial, endothelial and fibroblast cells express IL-17. Th17 cells are supposed to be involved in various autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Base on the biologic functions and regulation, IL-17 has regulatory roles in host defense and chronic inflammation which result in tissue damage and autoimmunity. So the IL-17 links links innate and adaptive immunity and has both beneficial and pathological effects on the immune system. This paper will focus on the possible roles of IL-17 in autoimmune diseases, a fundamental player in immune regulation.

Indexed as

autoimmunitycytokine receptorscytokinesinflammationinterleukin-17T cells

Identifiers

PMID25254011
PMCPMC4171672
OpenAlexW2041564493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.