ArticleToxicology international2014
Dose-dependent effect of deltamethrin in testis, liver, and kidney of wistar rats.
Article in Toxicology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies.Frontiers in endocrinology · 2021Pooled it
- Hesperidin Attenuates Deltamethrin-Induced Testicular Damage by Modulating Apoptosis-Associated Signaling and Profibrotic Gene Expression: Biochemical, Molecular, and Histological Evidence.Life (Basel, Switzerland) · 2026Article
- Gestational deltamethrin exposure exacerbates post-traumatic epileptiform activity and social deficits, diminishing the therapeutic efficacy of curcumin in rats.Metabolic brain disease · 2026Article
- Protective Role of Hesperidin Against Deltamethrin-Induced Cardiovascular Structural Damage: Involvement of Caspase-3-Driven Apoptosis and Fibrosis Suppression in Rats.Journal of cardiovascular development and disease · 2026Article
- A ready-to-use microsensor based on SERS technique for deltamethrin and its metabolite determination toward point-of-care diagnostics.Mikrochimica acta · 2026Article
- Assessment of the Oxidative Damage and Genotoxicity of Titanium Dioxide Nanoparticles and Exploring the Protective Role of Holy Basil Oil Nanoemulsions in Rats.Biological trace element research · 2023Article
- Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity.Acta cirurgica brasileira · 2023Article
- Subchronic toxicity of oral deltamethrin in laying chickens.Frontiers in veterinary science · 2022Article
- Article
- Elimination of oxidative stress and genotoxicity of biosynthesized titanium dioxide nanoparticles in rats via supplementation with whey protein-coated thyme essential oil.Environmental science and pollution research international · 2021Article
- Exposure to pesticides and oxidative stress in Brazilian agricultural communities.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2021Article
- Effect of diosmin on lipid peoxidation and organ damage against subacute deltamethrin exposure in rats.Environmental science and pollution research international · 2021Article
- Nano-curcumin versus curcumin in amelioration of deltamethrin-induced hippocampal damage.Histochemistry and cell biology · 2020Article
- Article
- Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal Neurons.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study.International journal of reproductive biomedicine · 2019Article
- Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes.International journal of fertility & sterility · 2018Article
- Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats.TheScientificWorldJournal · 2015Article
- Safety Evaluation of Various Vector Repellents in Combination with Deltamethrin in Wistar Rats.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDeltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, household pest control, protection of foodstuff, and disease vector control. Although initially thought to be least toxic, a number of recent reports showed its toxic effects in mammalian and non-mammalian animal species. The current study was performed to assess the dose-dependent deltamethrin toxicity on testes, liver, and kidney of male Wistar rats. MATERIALS AND
methodsTwenty-four rats were divided in four groups of 6 each. Group A served as normal control. Group B, C, and D were administered with different doses (2 or 3 or 6 mg/kg corresponding to 1/30(th) or 1/20(th) or 1/10(th) of LD50, respectively) of deltamethrin for 28 days.
resultsDeltamethrin exposure caused a significant reduction in weight of reproductive organs, decrease in sperm count, sperm motility, serum testosterone (T), follicle stimulating hormones (FSH), and luteinizing hormones (LH) in testis. Glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione S transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) were decreased in testis, liver and kidney of exposed rats. Deltamethrin exposure significantly increased sperm abnormalities in testis. Significant increase in lipid peroxidation (LPO) level was observed in testis, liver and kidney. Deltamethrin also caused histological alterations in testes, liver, and kidney.
conclusionsThe results indicated that deltamethrin at a dose of 6 mg/kg exerts significant harmful effects on testes, liver and kidney as compare to 2 mg and 3 mg/kg. The study concluded that the system toxicity induced by deltamethrin was dose dependent.
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