ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Two functionally distinct networks of gap junction-coupled inhibitory neurons in the thalamic reticular nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 67 citations in OpenAlex.
- Photomapping electrically coupled networks of the mature thalamus and cortex.Science advances · 2026Article
- Electrical Coupling within Thalamocortical Networks Cumulatively Reduces Cortical Correlation to Sensory Inputs.eNeuro · 2026Article
- Data-driven mouse motor thalamus model reveals topography and spatial weight scaling govern spindle dynamics.Communications biology · 2026Article
- Photomapping electrically coupled networks of the mature thalamus and cortex.bioRxiv : the preprint server for biology · 2026Article
- Closed-Loop Connectivity Best Supports Angular Tuning and Sleep Dynamics in a Biophysical Thalamocortical Circuit Model.bioRxiv : the preprint server for biology · 2025Article
- A multi-scale study of thalamic state-dependent responsiveness.PLoS computational biology · 2024Article
- Functionally Distinct Circuits Are Linked by Heterocellular Electrical Synapses in the Thalamic Reticular Nucleus.eNeuro · 2024Article
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- Article
- Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The synaptic inputs and thalamic projections of two classes of layer 6 corticothalamic neurons in primary somatosensory cortex of the mouse.The Journal of comparative neurology · 2021Article
- GABAInternational journal of molecular sciences · 2021Article
- Article
- Molecular and functional architecture of the mouse photoreceptor network.Science advances · 2020Article
- Article
- Early visual motion experience shapes the gap junction connections among direction selective ganglion cells.PLoS biology · 2020Article
- Effects of Propofol on Electrical Synaptic Strength in Coupling Reticular Thalamic GABAergic Parvalbumin-Expressing Neurons.Frontiers in neuroscience · 2020Article
- Thalamocortical Circuit Motifs: A General Framework.Neuron · 2019Review
- Thalamic inhibitory circuits and network activity development.Brain research · 2019Review
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gap junctions (GJs) electrically couple GABAergic neurons of the forebrain. The spatial organization of neuron clusters coupled by GJs is an important determinant of network function, yet it is poorly described for nearly all mammalian brain regions. Here we used a novel dye-coupling technique to show that GABAergic neurons in the thalamic reticular nucleus (TRN) of mice and rats form two types of GJ-coupled clusters with distinctive patterns and axonal projections. Most clusters are elongated narrowly along functional modules within the plane of the TRN, with axons that selectively inhibit local groups of relay neurons. However, some coupled clusters have neurons arrayed across the thickness of the TRN and target their axons to both first- and higher-order relay nuclei. Dye coupling was reduced, but not abolished, among cells of connexin36 knock-out mice. Our results suggest that GJs form two distinct types of inhibitory networks that correlate activity either within or across functional modules of the thalamus.
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