ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Reactive neurogenesis in response to naturally occurring apoptosis in an adult brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Parenchymal precursor cells act in concert with canonical neural progenitors to facilitate neural circuit recovery following neuronal loss.bioRxiv : the preprint server for biology · 2026Article
- The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons.Hippocampus · 2026Article
- A daily rhythm of cell proliferation in a songbird brain.Scientific reports · 2025Article
- Connectomes: from a sparsity of networks to large-scale databases.Frontiers in neuroinformatics · 2023Review
- Protective Effects of a Polyphenol-Rich Blueberry Extract on Adult Human Neural Progenitor Cells.Molecules (Basel, Switzerland) · 2022Article
- Consequences of adolescent alcohol use on adult hippocampal neurogenesis and hippocampal integrity.International review of neurobiology · 2021Review
- Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.Journal of neurotrauma · 2019Article
- Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system.Developmental neurobiology · 2019Article
- Seasonal changes in neuronal turnover in a forebrain nucleus in adult songbirds.The Journal of comparative neurology · 2019Article
- Sex Steroids, Adult Neurogenesis, and Inflammation in CNS Homeostasis, Degeneration, and Repair.Frontiers in endocrinology · 2018Review
- Retinal cell death dependent reactive proliferative gliosis in the mouse retina.Scientific reports · 2017Article
- Is behavioural flexibility evidence of cognitive complexity? How evolution can inform comparative cognition.Interface focus · 2017Article
- Adult Neurogenesis Leads to the Functional Reconstruction of a Telencephalic Neural Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Sex and age differences in brain-derived neurotrophic factor and vimentin in the zebra finch song system: Relationships to newly generated cells.The Journal of comparative neurology · 2016Article
- Network analysis of microRNA and mRNA seasonal dynamics in a highly plastic sensorimotor neural circuit.BMC genomics · 2015Article
- Neurogenesis in the adult avian song-control system.Cold Spring Harbor perspectives in biology · 2015Review
- Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity.Frontiers in neuroendocrinology · 2015Review
- Forniceal deep brain stimulation in a mouse model of Rett syndrome increases neurogenesis and hippocampal memory beyond the treatment period.Brain stimulationArticle
- Article
- Abnormal neurometabolites in fibromyalgia patients: Magnetic resonance spectroscopy study.Molecular painArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal birth and death are tightly coordinated to establish and maintain properly functioning neural circuits. Disruption of the equilibrium between neuronal birth and death following brain injury or pharmacological insult often induces reactive, and in some cases regenerative, neurogenesis. Many neurodegenerative disorders are not injury-induced, however, so it is critical to determine if and how reactive neurogenesis occurs under noninjury-induced neurodegenerative conditions. Here, we used a model of naturally occurring neural degradation in a neural circuit that controls song behavior in Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii) and examined the temporal dynamics between neuronal birth and death. We found that during seasonal-like regression of the song, control nucleus HVC (proper name), caspase-mediated apoptosis increased within 2 d following transition from breeding to nonbreeding conditions and neural stem-cell proliferation in the nearby ventricular zone (VZ) increased shortly thereafter. We show that inhibiting caspase-mediated apoptosis in HVC decreased neural stem-cell proliferation in the VZ. In baseline conditions the extent of neural stem-cell proliferation correlated positively with the number of dying cells in HVC. We demonstrate that as apoptosis increased and the number of both recently born and pre-existing neurons in HVC decreased, the structure of song, a learned sensorimotor behavior, degraded. Our data illustrate that reactive neurogenesis is not limited to injury-induced neuronal death, but also can result from normally occurring degradation of a telencephalic neural circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.