ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Rapid and slow chemical synaptic interactions of cholinergic projection neurons and GABAergic local interneurons in the insect antennal lobe.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Synergistic olfactory processing for social plasticity in desert locusts.Nature communications · 2024Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Article
- Odor processing in the cockroach antennal lobe-the network components.Cell and tissue research · 2021Review
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- Regeneration of synapses in the olfactory pathway of locusts after antennal deafferentation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Transient voltage-activated KJournal of neurophysiology · 2017Article
- Linking dynamics of the inhibitory network to the input structure.Journal of computational neuroscience · 2016Article
- Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons.Journal of neurophysiology · 2016Article
- Neuroethology of Olfactory-Guided Behavior and Its Potential Application in the Control of Harmful Insects.Frontiers in physiology · 2016Review
- Intrinsic and Network Mechanisms Constrain Neural Synchrony in the Moth Antennal Lobe.Frontiers in physiology · 2016Article
- Two types of local interneurons are distinguished by morphology, intrinsic membrane properties, and functional connectivity in the moth antennal lobe.Journal of neurophysiology · 2015Article
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2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The antennal lobe (AL) of insects constitutes the first synaptic relay and processing center of olfactory information, received from olfactory sensory neurons located on the antennae. Complex synaptic connectivity between olfactory neurons of the AL ultimately determines the spatial and temporal tuning profile of (output) projection neurons to odors. Here we used paired whole-cell patch-clamp recordings in the cockroach Periplaneta americana to characterize synaptic interactions between cholinergic uniglomerular projection neurons (uPNs) and GABAergic local interneurons (LNs), both of which are key components of the insect olfactory system. We found rapid, strong excitatory synaptic connections between uPNs and LNs. This rapid excitatory transmission was blocked by the nicotinic acetylcholine receptor blocker mecamylamine. IPSPs, elicited by synaptic input from a presynaptic LN, were recorded in both uPNs and LNs. IPSPs were composed of both slow, sustained components and fast, transient components which were coincident with presynaptic action potentials. The fast IPSPs were blocked by the GABAA receptor chloride channel blocker picrotoxin, whereas the slow sustained IPSPs were blocked by the GABAB receptor blocker CGP-54626. This is the first study to directly show the predicted dual fast- and slow-inhibitory action of LNs, which was predicted to be key in shaping complex odor responses in the AL of insects. We also provide the first direct characterization of rapid postsynaptic potentials coincident with presynaptic spikes between olfactory processing neurons in the AL.
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