ArticleCerebral cortex (New York, N.Y. : 1991)2015
A Tradeoff Between Accuracy and Flexibility in a Working Memory Circuit Endowed with Slow Feedback Mechanisms.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Disinhibition of a recurrent attractor gates a persistent goal signal for navigation.bioRxiv : the preprint server for biology · 2025Article
- Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance.Translational psychiatry · 2025Article
- Neural mechanisms balancing accuracy and flexibility in working memory and decision tasks.NPJ systems biology and applications · 2025Article
- Maintenance of delay-period activity in working memory task is modulated by local network structure.PLoS computational biology · 2024Article
- Single-pulse Transcranial Magnetic Stimulation Affects Working-memory Performance via Posterior Beta-band Oscillations.Journal of cognitive neuroscience · 2024Article
- Article
- 50 years of mnemonic persistent activity: quo vadis?Trends in neurosciences · 2021Review
- Quantifying the Landscape of Decision Making From Spiking Neural Networks.Frontiers in computational neuroscience · 2021Article
- Non-equilibrium landscape and flux reveal the stability-flexibility-energy tradeoff in working memory.PLoS computational biology · 2020Article
- Is It Possible to Improve Working Memory With Prefrontal tDCS? Bridging Currents to Working Memory Models.Frontiers in psychology · 2020Article
- Neural mechanisms of attending to items in working memory.Neuroscience and biobehavioral reviews · 2019Review
- Stability of working memory in continuous attractor networks under the control of short-term plasticity.PLoS computational biology · 2019Article
- Acquisition of temporal order requires an intact CA3 commissural/associational (C/A) feedback system in mice.Communications biology · 2019Article
- Random Recurrent Networks Near Criticality Capture the Broadband Power Distribution of Human ECoG Dynamics.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.The EMBO journal · 2017Article
- Stimulus Load and Oscillatory Activity in Higher Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Computational principles of memory.Nature neuroscience · 2016Review
- Computational psychiatry.Neuron · 2014Review
- Theory of Gating in Recurrent Neural Networks.Physical review. XArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies have shown that reverberation underlying mnemonic persistent activity must be slow, to ensure the stability of a working memory system and to give rise to long neural transients capable of accumulation of information over time. Is the slower the underlying process, the better? To address this question, we investigated 3 slow biophysical mechanisms that are activity-dependent and prominently present in the prefrontal cortex: Depolarization-induced suppression of inhibition (DSI), calcium-dependent nonspecific cationic current (ICAN), and short-term facilitation. Using a spiking network model for spatial working memory, we found that these processes enhance the memory accuracy by counteracting noise-induced drifts, heterogeneity-induced biases, and distractors. Furthermore, the incorporation of DSI and ICAN enlarges the range of network's parameter values required for working memory function. However, when a progressively slower process dominates the network, it becomes increasingly more difficult to erase a memory trace. We demonstrate this accuracy-flexibility tradeoff quantitatively and interpret it using a state-space analysis. Our results supports the scenario where N-methyl-d-aspartate receptor-dependent recurrent excitation is the workhorse for the maintenance of persistent activity, whereas slow synaptic or cellular processes contribute to the robustness of mnemonic function in a tradeoff that potentially can be adjusted according to behavioral demands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.