Evidence map›Paper›PMID 25253792›Full record

ArticleJournal of clinical microbiology2014

Evaluation of the Xpert Flu rapid PCR assay in high-risk emergency department patients.

Andrea F Dugas, Alexandra Valsamakis, Charlotte A Gaydos, Michael Forman, Justin Hardick, Pranav Kidambi, Sharmeen Amin, Alisha Gupta, Richard E Rothman

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Necessity to critically review the automatic results of the Xpert Flu assay.Diagnostic microbiology and infectious disease · 2017
    Article
  8. Review
  9. [Rapid diagnostic test for respiratory infections].Enfermedades infecciosas y microbiologia clinica · 2017
    Review
  10. Review
  11. Review
  12. Article
  13. Rapid diagnostic methods for acute viral respiratory infections.Enfermedades infecciosas y microbiologia clinica
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea F DugasDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, Maryland, USA adugas1@jhmi.edu.
Alexandra ValsamakisDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Charlotte A GaydosDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, Maryland, USA Department of Medicine, Division of Infectious Disease, Johns Hopkins University, Baltimore, Maryland, USA.
Michael FormanDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Justin HardickDepartment of Medicine, Division of Infectious Disease, Johns Hopkins University, Baltimore, Maryland, USA.
Pranav KidambiDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Sharmeen AminDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Alisha GuptaDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Richard E RothmanDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, Maryland, USA Department of Medicine, Division of Infectious Disease, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

Institute for Clinical and Translational Research (KL2)KL2RR025006 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$12.9M
NCRR NIH HHS 5KL2RR025006NCRR NIH HHS KL2 RR025006
6 · The paper itself

Abstract

We prospectively evaluated the performance of Cepheid's GeneXpert Xpert Flu assay in a target population of 281 adults presenting to the emergency department with an acute respiratory illness who met Centers for Disease Control and Prevention (CDC) criteria for recommended antiviral treatment. Compared with the Prodesse ProFlu+ assay, Xpert Flu had an overall sensitivity of 95.3% and specificity of 99.2%.

Indexed as

AdultEmergency Medical ServicesEmergency Service, HospitalFemaleHumansInfluenza, HumanMaleMiddle AgedMolecular Diagnostic TechniquesOrthomyxoviridaePolymerase Chain ReactionProspective StudiesSensitivity and Specificity

Identifiers

PMID25253792
PMCPMC4313313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.