ArticleNeurology2014
Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases.
Article in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 56 citations in OpenAlex.
- Multiparametric Quantitative MRI of Peripheral Nerves to Differentiate Demyelinating From Axonal Polyneuropathies.Journal of magnetic resonance imaging : JMRI · 2026Article
- Quantitative Neuromuscular MRI in CIDP Patients: Interest of a Multiparametric Approach.European journal of neurology · 2026Article
- Modeling Postoperative Nerve Regeneration Using Diffusion MRI: A Preclinical Study of a Novel Mathematical Approach.Muscle & nerve · 2026Article
- Multiparametric Quantitative MRI of Peripheral Nerves to Differentiate Demyelinating from Axonal Polyneuropathies.medRxiv : the preprint server for health sciences · 2025Article
- Quantitative MRI Assessment Using Variable Echo Time Imaging of Peripheral Nerve Injury in ATTRv Amyloidosis Patients.European journal of neurology · 2025Article
- Microstructural changes of peripheral nerves in early multiple sclerosis: A prospective magnetic resonance neurography study.European journal of neurology · 2024Article
- Multiparametric Quantitative MRI of Peripheral Nerves in the Leg: A Reliability Study.Journal of magnetic resonance imaging : JMRI · 2024Article
- Magnetization transfer ratio of the sciatic nerve differs between patients in type 1 and type 2 diabetes.European radiology experimental · 2024Article
- Advances in diagnosis and management of distal sensory polyneuropathies.Journal of neurology, neurosurgery, and psychiatry · 2023Review
- Feasibility of in vivo multi-parametric quantitative magnetic resonance imaging of the healthy sciatic nerve with a unified signal readout protocol.Scientific reports · 2023Article
- Magnetic resonance imaging and ultrasound elastography in the context of preclinical pharmacological research: significance for the 3R principles.Frontiers in pharmacology · 2023Review
- Magnetic resonance imaging-based lower limb muscle evaluation in Charcot-Marie-Tooth disease type 1A patients and its correlation with clinical data.Scientific reports · 2022Article
- Candidate imaging biomarkers for PMP22-related inherited neuropathies.Annals of clinical and translational neurology · 2022Article
- Magnetization Transfer Ratio of Peripheral Nerve and Skeletal Muscle : Correlation with Demographic Variables in Healthy Volunteers.Clinical neuroradiology · 2022Article
- Proximal nerve MR neurography with diffusion tensor imaging in differentiating subtypes of Charcot-Marie-Tooth disease.European radiology · 2022Article
- Reliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry.European radiology · 2021Article
- Magnetic Resonance Neurography: Improved Diagnosis of Peripheral Neuropathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Left to themselves: Time to target chronic pain in childhood rare diseases.Neuroscience and biobehavioral reviews · 2021Review
- Semi-Automatic MRI Muscle Volumetry to Diagnose and Monitor Hereditary and Acquired Polyneuropathies.Brain sciences · 2021Article
- Humans: the ultimate animal models.Journal of neurology, neurosurgery, and psychiatry · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objectives of this study were (1) to develop a novel magnetization transfer ratio (MTR) MRI assay of the proximal sciatic nerve (SN), which is inaccessible via current tools for assessing peripheral nerves, and (2) to evaluate the resulting MTR values as a potential biomarker of myelin content changes in patients with Charcot-Marie-Tooth (CMT) diseases.
methodsMTR was measured in the SN of patients with CMT type 1A (CMT1A, n = 10), CMT type 2A (CMT2A, n = 3), hereditary neuropathy with liability to pressure palsies (n = 3), and healthy controls (n = 21). Additional patients without a genetically confirmed subtype (n = 4), but whose family histories and electrophysiologic tests were consistent with CMT, were also included. The relationship between MTR and clinical neuropathy scores was assessed, and the interscan and inter-rater reliability of MTR was estimated.
resultsMean volumetric MTR values were significantly decreased in the SN of patients with CMT1A (33.8 ± 3.3 percent units) and CMT2A (31.5 ± 1.9 percent units) relative to controls (37.2 ± 2.3 percent units). A significant relationship between MTR and disability scores was also detected (p = 0.01 for genetically confirmed patients only, p = 0.04 for all patients). From interscan and inter-rater reliability analyses, proximal nerve MTR values were repeatable at the slicewise and mean volumetric levels.
conclusionsMTR measurements may be a viable biomarker of proximal nerve pathology in patients with CMT.
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