Evidence map›Paper›PMID 25253674›Full record

ArticleScience translational medicine2014

Clinical recovery from surgery correlates with single-cell immune signatures.

Brice Gaudillière, Gabriela K Fragiadakis, Robert V Bruggner, Monica Nicolau, Rachel Finck, Martha Tingle, Julian Silva, Edward A Ganio, Christine G Yeh, William J Maloney and 7 more

7 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 206 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02542592 phase2 / phase3completednot on this mapstarted 2015, after this paper: background citation

Effect of Preoperative Intravenous High Dose Methylprednisolone on Immune Signaling in Patients Scheduled for Total Hip-arthroplasty

TypeinterventionalSponsorRigshospitalet, DenmarkRan2015 to 2017Enrolled64ConditionsOsteoarthrosisArmsMethylprednisolone, Isotonic Sodium Chloride
NCT03611374 nacompletednot on this mapstarted 2019, after this paper: background citation

Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER) for Patients Undergoing Sternotomy for Congenital Heart Repair

TypeinterventionalSponsorStanford UniversityRan2019 to 2023Enrolled38ConditionsCongenital Heart Defect, Congenital Heart Disease, Anesthesia, Local, Opioid UseArmsBilateral Erector Spinae Plane Block (ESPB)
NCT03781440 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Regional Anesthesia for Cardiothoracic Enhanced Recovery for Patients Undergoing Cardiac Surgery Via Sternotomy

TypeinterventionalSponsorStanford UniversityRan2020 to 2023Enrolled60ConditionsOpioid Use, Anesthesia, Local, Cardiac Disease, Pain, AcuteArmsBilateral ESP catheter with lidocaine, Bilateral ESP catheter with saline
NCT03885713 phase4completednot on this mapstarted 2019, after this paper: background citation

Identification of Predictive Biomarkers for Response to Biologic Therapies and Tofacitinib in Inflammatory Bowel Disease by Proteomic and Mass Cytometry Approaches

TypeinterventionalSponsorFundación de Investigación Biomédica - Hospital Universitario de La PrincesaRan2019 to 2024Enrolled180ConditionsInflammatory Bowel Diseases, Crohn Disease, Ulcerative ColitisArmsInfliximab or adalimumab or golimumab or vedolizumab or ustekinumab or tofacitinib
NCT04498208 nacompletednot on this mapstarted 2020, after this paper: background citation

Immune System Modulation by Enhanced vs Standard Prehabilitation Program in Patients Undergoing Elective Major Surgery - a Prospective Monocentric Randomized Single-blinded Controlled Trial

TypeinterventionalSponsorStanford UniversityRan2020 to 2024Enrolled55ConditionsSurgery, Immune System and Related Disorders, Preoperative Care, Gastrointestinal DiseaseArmsPhysical Prehabilitation, Stress Reduction Prehabilitation, Cognitive Prehabilitation, Nutrition Prehabilitation
NCT04732000 phase2completednot on this mapstarted 2021, after this paper: background citation

Oxidative Stress and Surgical Recovery

TypeinterventionalSponsorStanford UniversityRan2021 to 2023Enrolled30ConditionsSurgical Recovery, Pain, PostoperativeArmsN-acetyl cysteine, Normal Saline
NCT05523713 nacompletednot on this mapstarted 2022, after this paper: background citation

Development and Validation of a Predictive Score for Surgical Site Infections (SSI): a Prospective Preoperative Trial in Major Digestive Surgery

TypeinterventionalSponsorHopital FochRan2022 to 2025Enrolled283ConditionsColon or Colorectal Resection, Partial or Total Gastrectomy, Pancreaticoduodenectomy, HepatectomyArmsPeripheral venous blood samples
3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Inflammatory Stewardship-A Perspective for Active Management of Acute Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Brice GaudillièreDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Baxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA.
Gabriela K FragiadakisBaxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Robert V BruggnerBaxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA. Biomedical Informatics Program, Stanford University, Stanford, CA 94305, USA.
Monica NicolauBaxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA. Department of Mathematics, Stanford University, Stanford, CA 94305, USA. Center for Cancer Systems Biology, Stanford University, Stanford, CA 94305, USA.
Rachel FinckBaxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Martha TingleDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Julian SilvaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Edward A GanioDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christine G YehDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
William J MaloneyDepartment of Orthopedic Surgery, Stanford University, Redwood City, CA 94063, USA.
James I HuddlestonDepartment of Orthopedic Surgery, Stanford University, Redwood City, CA 94063, USA.
Stuart B GoodmanDepartment of Orthopedic Surgery, Stanford University, Redwood City, CA 94063, USA.
Mark M DavisDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Sean C BendallBaxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Wendy J FantlBaxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA.
Martin S AngstDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. ang@stanford.edu gnolan@stanford.edu.
Garry P NolanBaxter Laboratory in Stem Cell Biology, Stanford University, Stanford, CA 94305, USA. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. ang@stanford.edu gnolan@stanford.edu.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NOLAN, GARRY P · 2012 to 2021
$49.1M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
TRIGGERING CELL DEATH IN B CELL LYMPHOMAP01CA034233 · NCI · STANFORD UNIVERSITY · PI TIBSHIRANI, ROB · 1985 to 2010
$19.5M
TRANS-NETWORK PROJECTSU54CA143907 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GROSS, MITCHELL E · 2009 to 2013
$15.2M
MODELING THE ROLE OF PROGRESSION IN FOLLICULAR LYMPHOMAU54CA149145 · NCI · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2010 to 2014
$12.1M
Software & Hardware Inference Engines for Automated Determination of Primary CellR01CA130826 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2008 to 2011
$6.7M
Research in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2M
A single-cell platform to discover and study regulators of human developmentR00GM104148 · NIGMS · STANFORD UNIVERSITY · PI BENDALL, SEAN CURTIS · 2014 to 2016
$747k
NCATS NIH HHS UL1 TR001085NCI NIH HHS 1R01CA130826NCI NIH HHS 5U54CA143907NCI NIH HHS P01 CA034233NCI NIH HHS P01CA034233-22A1NCI NIH HHS R01 CA130826NCI NIH HHS U54 CA143907NCI NIH HHS U54 CA149145NCI NIH HHS U54CA149145NCRR NIH HHS S10 RR027582NCRR NIH HHS S10RR027582-01NCRR NIH HHS UL1 RR025744NCRR NIH HHS UL1RR025744NHLBI NIH HHS HHSN268201000034CNHLBI NIH HHS N01-HV-00242NIAID NIH HHS 1U19AI100627NIAID NIH HHS U19 AI057229NIAID NIH HHS U19AI057229NIAID NIH HHS U19 AI100627NIGMS NIH HHS 1K99GM104148-01NIGMS NIH HHS K99 GM104148NIGMS NIH HHS R00 GM104148NIGMS NIH HHS T32 GM007276NIGMS NIH HHS T32GM007276NIGMS NIH HHS T32 GM089626NIGMS NIH HHS T32GM089626NLM NIH HHS 5T15LM007033-27NLM NIH HHS T15 LM007033PHS HHS 41000411217PHS HHS HHSF223201210194C
6 · The paper itself

Abstract

Delayed recovery from surgery causes personal suffering and substantial societal and economic costs. Whether immune mechanisms determine recovery after surgical trauma remains ill-defined. Single-cell mass cytometry was applied to serial whole-blood samples from 32 patients undergoing hip replacement to comprehensively characterize the phenotypic and functional immune response to surgical trauma. The simultaneous analysis of 14,000 phosphorylation events in precisely phenotyped immune cell subsets revealed uniform signaling responses among patients, demarcating a surgical immune signature. When regressed against clinical parameters of surgical recovery, including functional impairment and pain, strong correlations were found with STAT3 (signal transducer and activator of transcription), CREB (adenosine 3',5'-monophosphate response element-binding protein), and NF-κB (nuclear factor κB) signaling responses in subsets of CD14(+) monocytes (R = 0.7 to 0.8, false discovery rate <0.01). These sentinel results demonstrate the capacity of mass cytometry to survey the human immune system in a relevant clinical context. The mechanistically derived immune correlates point to diagnostic signatures, and potential therapeutic targets, that could postoperatively improve patient recovery.

Indexed as

Flow CytometryAgedArthroplasty, Replacement, HipBiomarkersCREB-Binding ProteinFemaleHip JointHumansImmunophenotypingLipopolysaccharide ReceptorsMaleMiddle AgedMonocytesNF-kappa BPhenotypePhosphorylationBiomarkersCREB-Binding ProteinCREBBP protein, humanLipopolysaccharide ReceptorsNF-kappa BSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID25253674
PMCPMC4334126

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.