Evidence map›Paper›PMID 25253288›Full record

ArticleGenes and immunity2014

Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients.

D C Jones, S Peacock, D Hughes, J A Traherne, R L Allen, M C N M Barnardo, P Friend, C J Taylor, S Fuggle, J Trowsdale and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Genes and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
  3. The Role of Killer Ig-like Receptors in Diseases from A to Z.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

D C JonesDepartment of Pathology, University of Cambridge, Cambridge, UK.
S PeacockTissue Typing Laboratory, Cambridge University Hospitals, Cambridge, UK.
D HughesNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
J A TraherneDepartment of Pathology, University of Cambridge, Cambridge, UK.
R L AllenCentre for Infection and Immunity, St. George's Hospital, University of London, London, UK.
M C N M BarnardoTransplant Immunology Laboratory, Churchill Hospital, Oxford, UK.
P FriendOxford Transplant Centre, Churchill Hospital, Oxford, UK.
C J TaylorTissue Typing Laboratory, Cambridge University Hospitals, Cambridge, UK.
S FuggleTransplant Immunology Laboratory, Churchill Hospital, Oxford, UK.
J TrowsdaleDepartment of Pathology, University of Cambridge, Cambridge, UK.
N T YoungDivision of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Churchill Hospital · GBUniversity of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBJohn Radcliffe Hospital · GBUniversity of Aberdeen · GBUniversity of London · GB

Funding

Medical Research Council G0901682Wellcome Trust 100140
6 · The paper itself

Abstract

Killer cell immunoglobulin-like receptors (KIR) are highly polymorphic members of the immunoglobulin superfamily, which influence the response of natural killer cells and some T-lymphocyte subsets. Analysis of a cohort of previously human cytomegalovirus (HCMV)-negative patients, who developed primary HCMV infection following HCMV-positive renal transplant (n=76), revealed an increase in the frequency of KIR genes located on the telomeric region of B haplotypes (Tel B). The presence of Tel B in combination with the KIR ligand HLA-C2 was significantly more frequent in this subgroup. These genetic factors were associated with resistance to HCMV infection in a second cohort (n=65), where the Tel B genes KIR2DL5, -2DS1, 2DS5 and -3DS1 were all significantly associated with high viral loads. Furthermore, the KIR haplotype Tel A when in combination with the KIR ligand HLA-C1 was significantly protective against the development of severe infection. Our results suggest that KIR are a significant factor in the control of primary HCMV infection, and that determination of KIR gene repertoire may help in detection of renal transplant patients who were most at risk.

Indexed as

Viral LoadCohort StudiesCytomegalovirusCytomegalovirus InfectionsGenetic Predisposition to DiseaseGenotypeHaplotypesHLA-C AntigensHost-Pathogen InteractionsHumansKidney TransplantationReceptors, KIRReceptors, KIR2DL5Receptors, KIR3DS1Risk FactorsSeverity of Illness IndexHLA-C AntigensKIR2DS1 protein, humanKIR2DS5 protein, humanReceptors, KIRReceptors, KIR2DL5Receptors, KIR3DS1

Identifiers

PMID25253288
OpenAlexW1976669171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.