ArticleBMC cancer2014
Btbd7 contributes to reduced E-cadherin expression and predicts poor prognosis in non-small cell lung cancer.
Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Nit1 is upregulated in non-small cell lung cancer and promotes cancer cell proliferation and invasion and regulates EMT-related molecules and cyclins.Journal of Cancer · 2025Article
- CircZCCHC2 (hsa_circ_0000854) promotes hepatocellular carcinoma progression through modulating miR-936/BTBD7 axis and activating Rho/ROCK2 pathway.Non-coding RNA research · 2024Article
- High BTBD7 expression positive is correlated with SLUG-predicted poor prognosis in hormone receptor-negative breast cancer.Annals of translational medicine · 2021Article
- ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/β-catenin signaling.International journal of medical sciences · 2021Article
- Artesunate inhibits epithelial-mesenchymal transition in non-small-cell lung cancer (NSCLC) cells by down-regulating the expression ofBioengineered · 2020Article
- Tumor evolution in epidermal growth factor receptor mutated non-small cell lung cancer.Journal of thoracic disease · 2020Review
- Ube2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer.International journal of medical sciences · 2020Article
- Sleeping beauty genetic screen identifies miR-23b::BTBD7 gene interaction as crucial for colorectal cancer metastasis.EBioMedicine · 2019Article
- Clinical significance of epithelial-mesenchymal transition-related molecules in lung adenocarcinoma.Current oncology (Toronto, Ont.) · 2019Article
- Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila.PLoS genetics · 2019Article
- BTBD7 Downregulates E-Cadherin and Promotes Epithelial-Mesenchymal Transition in Lung Cancer.BioMed research international · 2019Article
- Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.International journal of medical sciences · 2019Article
- Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?Cells · 2018Review
- SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients.Cancer medicine · 2018Article
- Integrin αvβ6 Promotes Lung Cancer Proliferation and Metastasis through Upregulation of IL-8-Mediated MAPK/ERK Signaling.Translational oncology · 2018Article
- Effects of Btbd7 knockdown on the proliferation of human dental pulp cells and expression of Dspp.International journal of clinical and experimental pathology · 2018Article
- MDM2 binding protein as a predictor of metastasis and a novel prognostic biomarker in patients with gastric cancer.Oncology letters · 2017Article
- RETRACTED: Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesisDevelopment (Cambridge, England) · 2017Article
- Silencing of Btbd7 Inhibited Epithelial-Mesenchymal Transition and Chemoresistance in CD133Oncology research · 2017Article
- Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D.ACS biomaterials science & engineering · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisorders of cell adhesion are critical steps in cancer progression in which varieties of markers including cadherins are involved in.Btbd7 was found to inhibit E-cadherin expression in MDCK cells and play important roles during branching morphogenesis of embryonic salivary glands and lungs. However its function in malignant tumors is largely unknown. The aim of this study is to investigate the clinicopathological significance and possible function of Btbd7 in non-small cell lung cancer.
methodsImmunohistochemistry and Western blotting were used to investigate Btbd7 expression in non-small cell lung cancer and lung tissues. The clinicopathological association and the overall survival was analyzed. In vitro experiments were performed using siRNA to investigate the function of Btbd7 in lung cancer cells.
resultsBtbd7 expression was elevated in non-small cell lung cancer tissues compared to normal lung tissues. Increased Btbd7 expression was significantly associated with lymph node metastasis, reduced E-cadherin expression and patients' poor clinical outcome. Downregulation of Btbd7 expression in lung cancer cells by siRNA significantly inhibits cancer cell invasion and effectively restores E-cadherin expression in cancer cell membrane.
conclusionsBtbd7 contributes to reduced expression of E-cadherin and may be a promising cancer marker in non-small cell lung cancer.
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