Evidence map›Paper›PMID 25252870›Full record

ArticleLeukemia2015

Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation.

J Steger, E Füller, M-P Garcia-Cuellar, K Hetzner, R K Slany

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  3. Article
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  9. Myeloid transformation byLife science alliance · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Deregulation of the HOXA9/MEIS1 axis in acute leukemia.Current opinion in hematology · 2016
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J StegerDepartment of Genetics, University of Erlangen, Erlangen, Germany.
E FüllerDepartment of Genetics, University of Erlangen, Erlangen, Germany.
M-P Garcia-CuellarDepartment of Genetics, University of Erlangen, Erlangen, Germany.
K HetznerDepartment of Genetics, University of Erlangen, Erlangen, Germany.
R K SlanyDepartment of Genetics, University of Erlangen, Erlangen, Germany.ORCID 0000000220289759
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HOX homeobox proteins are key oncogenic drivers in hematopoietic malignancies. Here we demonstrate that HOXA1, HOXA6 and predominantly HOXA9 are able to induce the production of insulin-like growth factor 1 (Igf1). In chromatin immunoprecipitations, HOXA9 bound directly to the putative promoter and a DNase-hypersensitive region in the first intron of the Igf1 gene. Transcription rates of the Igf1 gene paralleled HOXA9 activity. Primary cells transformed by HOXA9 expressed functional Igf1 receptors and activated the protein kinase Akt in response to Igf1 stimulation, suggesting the existence of an autocrine signaling loop. Genomic deletion of the Igf1 gene by Cre-mediated recombination increased sensitivity toward apoptosis after serum starvation. In addition, the leukemogenic potential of Igf1-negative, HOXA9-transformed cells was impaired, leading to a significant delay in disease development on transplantation into recipient animals.

Indexed as

Gene Expression Regulation, LeukemicAnimalsApoptosisCell Transformation, NeoplasticDisease Models, AnimalFeedback, PhysiologicalHomeobox A1 ProteinHomeodomain ProteinsInsulin-Like Growth Factor ILeukemiaLymphocytesMiceMice, KnockoutPrimary Cell CulturePromoter Regions, GeneticProtein BindingHomeobox A1 Proteinhomeobox protein HOXA9Homeodomain ProteinsHoxa6 protein, mouseInsulin-Like Growth Factor IProto-Oncogene Proteins c-aktTranscription Factors

Identifiers

PMID25252870
OpenAlexW2319516509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.