ArticleScientific reports2014
A thiazole coumarin (TC) turn-on fluorescence probe for AT-base pair detection and multipurpose applications in different biological systems.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 55 citations in OpenAlex.
- Targeting Oncogene Promoters and Ribosomal RNA Biogenesis by G-Quadruplex Binding Ligands Translate to Anticancer Activity.ACS bio & med chem Au · 2022Article
- Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences.Inorganic chemistry · 2021Article
- Article
- Recognition of G-quadruplex topology through hybrid binding with implications in cancer theranostics.Theranostics · 2020Article
- Benzocoumarin-Styryl Hybrids: Aggregation and Viscosity Induced Emission Enhancement.Journal of fluorescence · 2017Article
- Design, Synthesis and Evaluation of Bifunctional Acridinine-Naphthalenediimide Redox-Active Conjugates as Antimalarials.ACS omega · 2016Article
- Stimuli-responsive colorimetric and NIR fluorescence combination probe for selective reporting of cellular hydrogen peroxide.Chemical science · 2016Article
- A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates.Scientific reports · 2016Article
- Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications.Nucleic acids research · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
Sequence-specific recognition of DNA by small turn-on fluorescence probes is a promising tool for bioimaging, bioanalytical and biomedical applications. Here, the authors report a novel cell-permeable and red fluorescent hemicyanine-based thiazole coumarin (TC) probe for DNA recognition, nuclear staining and cell cycle analysis. TC exhibited strong fluorescence enhancement in the presence of DNA containing AT-base pairs, but did not fluoresce with GC sequences, single-stranded DNA, RNA and proteins. The fluorescence staining of HeLa S3 and HEK 293 cells by TC followed by DNase and RNase digestion studies depicted the selective staining of DNA in the nucleus over the cytoplasmic region. Fluorescence-activated cell sorting (FACS) analysis by flow cytometry demonstrated the potential application of TC in cell cycle analysis in HEK 293 cells. Metaphase chromosome and malaria parasite DNA imaging studies further confirmed the in vivo diagnostic and therapeutic applications of probe TC. Probe TC may find multiple applications in fluorescence spectroscopy, diagnostics, bioimaging and molecular and cell biology.
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