ArticleAnatolian journal of cardiology2015
Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major.
Article in Anatolian journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Cardiovascular magnetic resonance native TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Pooled it
- Fragmented QRS duration as a marker of cardiac and hepatic iron overload: across-sectional study.Scientific reports · 2025Article
- Evaluation of iron overload in visceral organs in thalassemia patients by point shear-wave elastography.Irish journal of medical science · 2024Article
- Evaluation of electrocardiography, echocardiography and cardiac T2* for cardiac complications in beta thalassemia major.The international journal of cardiovascular imaging · 2022Article
- High prevalence of fragmented QRS on electrocardiography in Japanese patients with diabetes irrespective of metabolic syndrome.Journal of diabetes investigation · 2021Review
- Twelve-lead and signal-averaged electrocardiographic parameters among beta-thalassemia major patients.Journal of arrhythmia · 2020Article
- The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major.Pulse (Basel, Switzerland) · 2020Article
- Arrhythmias and Sudden Cardiac Death in Beta-Thalassemia Major Patients: Noninvasive Diagnostic Tools and Early Markers.Cardiology research and practice · 2019Review
- Author's Reply.Anatolian journal of cardiology · 2015Article
- Iron overload and fragmented QRS in patients with Thalassemia major: Mechanisms, therapies, and new horizons.Anatolian journal of cardiology · 2015Article
Corrections and comments
- Commented on by
- Commented on byAuthor's Reply.2015
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBeta-thalassemia major (TM) is a genetic hemoglobin disorder causing chronic hemolytic anemia. Since cardiac insufficiency and arrhythmias are the primary causes of mortality in such patients, monitoring of cardiac iron load is important in management of the disorder. The purpose of this study was to investigate the importance of fragmented QRS (fQRS) and its relation to the cardiac T2* value for the evaluation of cardiac iron load in TM patients.
methodsThis retrospective study included 103 TM patients. The patients' T2* values, measured by cardiac MRI and 12-lead surface ECGs, were interpreted. The cardiac T2* values under 20 were considered as cardiac iron overload. The relationship between the cardiac T2* value and fQRS in ECG was investigated.
resultsThe median age of the patients was 22.6 ± 6.6 years. All patients were on regular blood transfusions and iron chelators. The patients had no risk factors for coronary artery disease. In 50 (48%) patients fQRS was detected, and in 37 (74%) of these the T2* values were low. 86% of patients with cardiac involvement (37) had fQRS, but 22% of patients with non-involvement (13) had fQRS (p < 0.001).
conclusionSince cardiac involvement is the primary cause of mortality in TM patients, the early diagnosis of cardiac dysfunction is of vital importance. The search for fQRS in the ECGs of these patients, particularly when cardiac T2* values cannot be determined and followed, is a non-expensive and easy-to-attain method for therapy management.
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