Evidence map›Paper›PMID 25252079›Full record

SynthesisThe Prostate2014

8q24 risk alleles and prostate cancer in African-Barbadian men.

Cheryl D Cropp, Christiane M Robbins, Xin Sheng, Anselm J M Hennis, John D Carpten, Lyndon Waterman, Ronald Worrell, Tae-Hwi Schwantes-An, Jeffrey M Trent, Christopher A Haiman and 4 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Prostate, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  15. Variants on 8q24 and prostate cancer risk in Chinese population: a meta-analysis.International journal of clinical and experimental medicine · 2015
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Cheryl D CroppComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland.
Christiane M Robbins
Xin Sheng
Anselm J M Hennis
John D Carpten
Lyndon Waterman
Ronald Worrell
Tae-Hwi Schwantes-An
Jeffrey M Trent
Christopher A Haiman
M Cristina Leske
Suh-Yuh Wu
Joan E Bailey-Wilson
Barbara Nemesure
Stony Brook University Hospital · USTranslational Genomics Research Institute · USUniversity of the West Indies · BBNational Institutes of Health · USUniversity of Southern California · USNational Human Genome Research Institute · US

Funding

Genetic Epidemiology of CancerZIAHG200331 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$11.7M
Prostate Cancer in a Black PopulationR01CA114379 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI NEMESURE, BARBARA · 2007 to 2011
$3.9M
Human and ecological health risk factors in the Pacific BasinR13ES025487 · NIEHS · UNIVERSITY OF ARIZONA · PI ARNOLD, ROBERT GLENN · 2015 to 2015
$53k
Intramural NIH HHS Z99 HG999999Intramural NIH HHS ZIA HG200331NCI NIH HHS R01 CA114379NCI NIH HHS R01CA114379NIEHS NIH HHS N01 HG025487
6 · The paper itself

Abstract

backgroundAfrican American men (AA) exhibit a disproportionate share of prostate cancer (PRCA) incidence, morbidity, and mortality. Several genetic association studies have implicated select 8q24 loci in PRCA risk in AA. The objective of this investigation is to evaluate the association between previously reported 8q24 risk alleles and PRCA in African-Barbadian (AB) men known to have high rates of PRCA.

methodsTen previously reported candidate tag SNPs were genotyped and/or imputed in the 8q24 region in 532 AB men with PRCA and 513 AB controls from the Prostate Cancer in a Black Population (PCBP) study.

resultsRs2124036 was significant in AB men, (OR = 2.7, 95% CI (1.3-5.3), P = 0.005, Empirical (max (T), corrected for multiple testing) P = 0.03) for the homozygous C/C genotype. Only a single SNP from this region remained statistically significant in our analysis of our AB population. These results may indicate the presence of a founder effect or due to the chosen SNPs not tagging an ancestral haplotype bearing the 8q24 risk allele(s) in this population or could reflect inadequate power to detect an association. We conducted a meta-analysis including our AB population along with two additional African Caribbean populations from Tobago and Jamaica for SNPs rs16901979 and rs1447295. Meta-analysis results were most significant for rs16901979 A allele (Z score 2.73; P = 0.006) with a summary OR = 1.31 (95% CI: 1.09-1.58).

conclusionsAdditional studies are needed to provide deeper genotype coverage to further interrogate the 8q24 region to understand its contribution to PRCA in this population.

Indexed as

AllelesAfricaBarbadosCaribbean RegionCase-Control StudiesChromosomes, Human, Pair 8Genetic Predisposition to DiseaseGenotypeHaplotypesHumansIncidenceMalePolymorphism, Single NucleotideProstatic NeoplasmsRisk Factors8q24associationCaribbean and risk factorsgeneticprostate cancer

Identifiers

PMID25252079
PMCPMC4322001
OpenAlexW1918866443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.