Evidence map›Paper›PMID 25251851›Full record

ReviewAnnual review of genetics2014

Regulation of transcription by long noncoding RNAs.

Roberto Bonasio, Ramin Shiekhattar

Registry-linked trialAbstract readReview
In one paragraph

Review in Annual review of genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04729855 (Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population), which is not on this map. Cited by 264 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04729855 completednot on this mapstarted 2022, after this paper: background citation

Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population

TypeobservationalSponsorEsraa Hassan,MDRan2022 to 2024Enrolled60ConditionsColo-rectal CancerArmsPBMCs and Tissue expression of HOTTIP ,EIF4EBP1 and serum SNP HOTTIP rs1859168
3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Computational Prediction of Gene Regulation by lncRNAs.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Review
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  12. Article
  13. Article
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  20. Review

204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Roberto BonasioDepartment of Cell and Developmental Biology and Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email: rbon@mail.med.upenn.edu.
Ramin Shiekhattar

Funding

Elucidation of Integrator's FunctionR01GM078455 · NIGMS · WISTAR INSTITUTE · PI SHIEKHATTAR, RAMIN · 2010 to 2025
$5.1M
Non-coding RNAs in Transcription and Chromatin ArchitectureR01GM105754 · NIGMS · WISTAR INSTITUTE · PI SHIEKHATTAR, RAMIN · 2014 to 2017
$1.7M
NIGMS NIH HHS R01 GM 078455NIGMS NIH HHS R01 GM078455NIGMS NIH HHS R01 GM 105754NIGMS NIH HHS R01 GM105754
6 · The paper itself

Abstract

Over the past decade there has been a greater understanding of genomic complexity in eukaryotes ushered in by the immense technological advances in high-throughput sequencing of DNA and its corresponding RNA transcripts. This has resulted in the realization that beyond protein-coding genes, there are a large number of transcripts that do not encode for proteins and, therefore, may perform their function through RNA sequences and/or through secondary and tertiary structural determinants. This review is focused on the latest findings on a class of noncoding RNAs that are relatively large (>200 nucleotides), display nuclear localization, and use different strategies to regulate transcription. These are exciting times for discovering the biological scope and the mechanism of action for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function, and transcriptional regulation, with a great impact on development and disease.

Indexed as

Enhancer Elements, GeneticTranscription, GeneticAnimalsChromatinDosage Compensation, GeneticDrosophilaGene SilencingHigh-Throughput Nucleotide SequencingMammalsRNA, Long NoncodingRNA Polymerase IIChromatinRNA, Long NoncodingRNA Polymerase IIchromatinchromatin-modifying complexesenhancersimprintingRNA polymerase IItranscriptional silencing

Identifiers

PMID25251851
PMCPMC4285387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.