ArticleAddiction (Abingdon, England)2015
Tests of the effects of adolescent early alcohol exposures on adult outcomes.
Article in Addiction (Abingdon, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06221839 (Structural Racism, Neurocognition in Reward Related Decision Making and Substance Use Risk), which is not on this map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Structural Racism, Neurocognition in Reward Related Decision Making and Substance Use Risk
Who cites it
35 citing papers in PubMed.
- Effect of Selective Personality-Targeted Alcohol Use Prevention on 7-Year Alcohol-Related Outcomes Among High-risk Adolescents: A Secondary Analysis of a Cluster Randomized Clinical Trial.JAMA network open · 2022Trial
- The HOPE program: protocol for a stratified cluster randomized controlled trial to prevent psychoactive substance use and promote health in Moroccan middle school students.Addiction science & clinical practice · 2026Article
- Behavioral Disinhibition Model of Addiction: A Review and New Findings from the Minnesota Twin Family Study.Behavior genetics · 2026Review
- Structural stressors, neurocognition in reward-related decision making and substance use risk in Puerto Rican early adolescents at two sites: study design.Frontiers in public health · 2026Observational
- Examining the continuity of modifiable cancer-risk behaviors from youth into adulthood through prospective longitudinal studies: A scoping review.Social science & medicine (1982) · 2025Article
- Directional associations between antisocial behavior and alcohol use disorder symptoms from adolescence through adulthood: A sibling comparison cross-lagged approach.Alcohol, clinical & experimental research · 2025Article
- Prevention of hazardous use of alcohol among high school students: a study protocol for the randomized controlled trial 'Our choice'.BMC public health · 2023Article
- Alternative hypotheses regarding the association between early engagement in gambling and gambling-like activities and later problem gambling - a commentary on Richard and King (2023).Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Exploring the relationships between adolescent alcohol misuse and later life health outcomes.Alcoholism, clinical and experimental research · 2022Article
- Early life stress and substance use disorders: The critical role of adolescent substance use.Pharmacology, biochemistry, and behavior · 2022Review
- Adolescent substance use: Findings from a state-wide pilot parent education program.BMC public health · 2022Article
- The role of substance use coping in linking depression and alcohol use from late adolescence through early adulthood.Experimental and clinical psychopharmacology · 2021Article
- Predicting Alcohol Dependence Symptoms by Young Adulthood: A Co-Twin Comparisons Study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2021Article
- Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples.Psychological medicine · 2021Article
- Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use.Psychological medicine · 2021Article
- Chronic Ethanol Exposure during Adolescence Increases Voluntary Ethanol Consumption in Adulthood in Female Sprague Dawley Rats.Brain sciences · 2020Article
- Which adolescent factors predict alcohol misuse in young adulthood? A co-twin comparisons study.Addiction (Abingdon, England) · 2020Article
- Social Interaction With an Alcohol-Intoxicated or Cocaine-Injected Peer Selectively Alters Social Behaviors and Drinking in Adolescent Male and Female Rats.Alcoholism, clinical and experimental research · 2019Article
- Predicting hazardous drinking in late adolescence/young adulthood from early and excessive adolescent drinking - a longitudinal cross-national study of Norwegian and Australian adolescents.BMC public health · 2019Article
- The Importance of Intimate Partner Violence in Within-Relationship and Between-Person Risk for Alcohol-Exposed Pregnancy.Alcoholism, clinical and experimental research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
aimsTo determine whether early adolescent alcohol use contributes to adult alcohol use, misuse and other adult substance-related and social outcomes.
designIn a longitudinal study of twins assessed at target ages 11, 14 and 24 years, two techniques adjusted for confounding factors: a propensity score (PS) adjusting for the effects of measured background covariates and co-twin control (CTC) adjusting for confounding by unmeasured (including genetic) factors shared within early alcohol exposure-discordant pairs.
settingThe community-based Minnesota Twin Family Study.
participantsA total of 1512 (50.3% female) twins. MEASUREMENTS: Early adolescent alcohol exposures, adult substance-related and social outcomes and background variables reflecting behavioral, familial and environmental characteristics.
findingsBackground covariates unbalanced between those with and without early alcohol exposure were balanced through PS-based weighting, leaving several adult outcomes related to substance use or social functioning remaining significantly associated with early alcohol exposure. Similarly, the within-pair individual-level component of a CTC indicated that early alcohol-exposed twins had higher risk than their non-exposed co-twins for several, but not all, of the same adult outcomes. For example, early alcohol use was associated with an adult index of alcohol use in both PS-weighted (β = 0.57, P < 0.001) and CTC (β = 0.21, P = 0.031) analyses.
conclusionsEarly alcohol exposures predict adult alcohol problems and related outcomes, despite stringent adjustment for measured and non-measured sources of potential confounding using propensity score and co-twin control. Contrasting the methods indicated that exposure effect estimates from PS application were likely biased by unmeasured confounding factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.