Trial reportClinical and experimental immunology2015
Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis.
Trial report in Clinical and experimental immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus.Journal of clinical immunology · 2019Pooled it
- Insufficient serum L-ficolin is associated with disease presence and extent of pulmonary Mycobacterium avium complex disease.Respiratory research · 2019Trial
- Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns.Frontiers in immunology · 2023Article
- Association of theInternational journal of molecular sciences · 2022Article
- Human Amnion-Derived Mesenchymal Stromal Cells: A New Potential Treatment for Carbapenem-ResistantInternational journal of molecular sciences · 2022Article
- The Plasma Proteome Fingerprint Associated with Circulating Carotenoids and Retinol in Older Adults.The Journal of nutrition · 2022Article
- Polymorphisms of theFrontiers in immunology · 2021Article
- Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces.European journal of immunology · 2020Review
- 9q34 & 16p13 chromosome duplications in autism.AME case reports · 2020Article
- Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: a cross-sectional study.Arthritis research & therapy · 2019Observational
- Lectin pathway factors in patients suffering from juvenile idiopathic arthritis.Immunology and cell biology · 2017Article
- Frequency and distribution of FCN2 and FCN3 functional variants among MBL2 genotypes.Immunogenetics · 2016Article
- Six-SOMAmer Index Relating to Immune, Protease and Angiogenic Functions Predicts Progression in IPF.PloS one · 2016Article
- Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating Leukocytes.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Association of the FCN2 Gene Single Nucleotide Polymorphisms with Susceptibility to Pulmonary Tuberculosis.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) encompasses a heterogeneous group of antibody deficiencies characterized by susceptibility to recurrent infections and sequelae, including bronchiectasis. We investigated the relevance of the lectin complement pathway in CVID patients by analysing ficolin-2 and ficolin-3 serum levels and genotyping single nucleotide polymorphisms (SNPs) in the FCN2 and FCN3 genes. Our results show that ficolin-2 levels in CVID patients are significantly lower (P < 0.0001) than in controls. The lowest ficolin-2 levels are found in CVID patients with bronchiectasis (P = 0.0004) and autoimmunity (P = 0.04). Although serum levels of ficolin-3 were similar in CVID patients and controls, CVID patients with bronchiectasis again showed lower levels when compared to controls (P = 0.0001). Analysis of single nucleotide polymorphisms in the FCN2 gene confirmed known influences on ficolin-2 serum levels, but did not support a genetic basis for the observed ficolin-2 deficiency in CVID. We found that CVID patients with bronchiectasis have very low levels of ficolin-2. The reason for the deficiency of ficolin-2 in CVID and any possible causal relationship is currently unknown. However, as bronchiectasis is a very important factor for morbidity and mortality in CVID, ficolin-2 could also serve as biomarker for monitoring disease complications such as bronchiectasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.