ArticleThe American journal of the medical sciences2015
Predictive factors for metastatic infection in patients with bacteremia caused by methicillin-sensitive Staphylococcus aureus.
Article in The American journal of the medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05522764 (Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity), which is not on this map. Cited by 33 papers.
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The trial behind it
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Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity
Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- BACT-URIE: A Novel Score Integrating Bacteriuria to Predict Infective Endocarditis in Patients WithOpen forum infectious diseases · 2026Article
- Predictors of osteo-articular infection inJournal of bone and joint infection · 2026Article
- Clinical characteristics and risk factors for pathological fractures in children with Staphylococcus aureus osteoarticular infections: a retrospective cohort study.Italian journal of pediatrics · 2025Article
- Analysis of clinical characteristics and risk factors for Staphylococcus aureus disseminated infection secondary to acute osteoarticular infections in children.Italian journal of pediatrics · 2025Article
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- The Utility of Gallium Scan in Patients With Perinephric Abscess and Septic Pulmonary Emboli in the Absence of Right-Sided Infective Endocarditis: A Case Report.Case reports in infectious diseases · 2025Article
- Distinct Clinical Endpoints of Staphylococcus aureus Bacteraemia Complicate Assessment of Outcome.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Observational
- [Antibiotics (Basel, Switzerland) · 2024Article
- The Utility of Risk Factors to Define Complicated Staphylococcus aureus Bacteremia in a Setting With Low Methicillin-Resistant S. aureus Prevalence.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Risk Factors and Outcomes of Hematogenous Vertebral Osteomyelitis in Patients With Staphylococcus aureus Bacteremia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia.Scientific reports · 2023Article
- A Severe Case of Disseminated Multifocal Methicillin-Susceptible Staphylococcal Infection in a Diabetic Patient.Cureus · 2022Article
- Intercostal Muscle Abscesses in Infective Endocarditis Associated With Migratory Deposition of Calcium Pyrophosphate.Cureus · 2022Article
- C-reactive protein predicts persistent bacteremia caused by community-acquired methicillin-resistant Staphylococcus aureus strain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Risk Factors of Coexisting Septic Spondylitis and Arthritis: A Case-Control Study in a Tertiary Referral Hospital.Journal of clinical medicine · 2021Article
- Case report: appendicitis induced Staphylococcus aureus and Klebsiella pneumoniae bacteremia in a young healthy male.International journal of emergency medicine · 2021Article
- C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study.BMC infectious diseases · 2021Article
- Bloodstream infections in the elderly: what is the real goal?Aging clinical and experimental research · 2021Review
- The STAPH Score: A Predictor ofOpen forum infectious diseases · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastatic infections such as infective endocarditis and psoas abscess are serious complications of Staphylococcus aureus bacteremia because failure to identify these infections may result in bacteremia relapse or poor prognosis. In the present study, we determined the predictive factors for metastatic infection due to methicillin-sensitive S. aureus bacteremia.
methodsA retrospective cohort study was conducted among patients with methicillin-sensitive S. aureus bacteremia at the Jikei University Hospital between January 2008 and December 2012. Factors analyzed included the underlying disease, initial antimicrobial treatment and primary site of infection.
resultsDuring the 5-year study period, 73 patients met the inclusion criteria and were assessed. The most common primary site of bacteremia was catheter-related bloodstream infection (25/73 [34.2%]). Metastatic infection occurred in 14 of 73 patients (19.2%) (infective endocarditis [3], septic pulmonary abscess [3], spondylitis [4], psoas abscess [4], epidural abscess [3] and septic arthritis [1]). Six patients had multiple metastatic infections. Multivariate analysis revealed that the predictive factors associated with the development of metastatic infection were a delay in appropriate antimicrobial treatment of >48 hours, persistent fever for >72 hours after starting antibiotic treatment and lowest C-reactive protein levels of >3 mg/dL during 2 weeks after the onset of bacteremia.
conclusionsThis study demonstrated that additional diagnostic tests should be conducted to identify metastatic infection, particularly in patients with delayed antimicrobial treatment, persistent fever and persistently high C-reactive protein levels.
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