Evidence map›Paper›PMID 25250717›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2014

Transmission of methicillin-resistant Staphylococcus aureus infection through solid organ transplantation: confirmation via whole genome sequencing.

J M Wendt, D Kaul, B M Limbago, M Ramesh, S Cohle, A M Denison, E M Driebe, J K Rasheed, S R Zaki, D M Blau and 8 more

Abstract readCase Reports
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Impact of donor multidrug-resistant organisms on solid organ transplant recipient outcomes.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

J M WendtCenters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA; Centers for Disease Control and Prevention, Epidemic Intelligence Service, Office of Surveillance Epidemiology and Laboratory Services, Atlanta, GA.
D Kaul
B M Limbago
M Ramesh
S Cohle
A M Denison
E M Driebe
J K Rasheed
S R Zaki
D M Blau
C D Paddock
L K McDougal
D M Engelthaler
P S Keim
C C Roe
H Akselrod
M J Kuehnert
S V Basavaraju
Centers for Disease Control and Prevention · USTranslational Genomics Research Institute · USNational Center for Emerging and Zoonotic Infectious Diseases · USCenter for Surveillance, Epidemiology, and Laboratory Services · USHenry Ford Health System · USIcahn School of Medicine at Mount Sinai · USKing County Medical Examiner's Office · USUniversity of Michigan–Ann Arbor · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

We describe two cases of donor-derived methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that developed after transplantation of organs from a common donor who died from acute MRSA endocarditis. Both recipients developed recurrent MRSA infection despite appropriate antibiotic therapy, and required prolonged hospitalization and hospital readmission. Comparison of S. aureus whole genome sequence of DNA extracted from fixed donor tissue and recipients' isolates confirmed donor-derived transmission. Current guidelines emphasize the risk posed by donors with bacteremia from multidrug-resistant organisms. This investigation suggests that, particularly in the setting of donor endocarditis, even a standard course of prophylactic antibiotics may not be sufficient to prevent donor-derived infection.

Indexed as

Genome, BacterialSequence Analysis, DNATissue DonorsDNA, BacterialHumansMaleMethicillin-Resistant Staphylococcus aureusOrgan TransplantationPolymorphism, Single NucleotideStaphylococcal InfectionsDNA, Bacterial

Identifiers

PMID25250717
PMCPMC4620542
OpenAlexW1937772535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.