Evidence map›Paper›PMID 25250710›Full record

ArticleeLife2014

How the immune system spots tumors.

Yasutaka Okabe, Ruslan Medzhitov

Open access · goldAbstract readComment
In one paragraph

Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yasutaka OkabeYasutaka Okabe is in the Department of Immunobiology, Yale University School of Medicine, New Haven, United States.
Ruslan MedzhitovRuslan Medzhitov is an eLife reviewing editor, and is in the Department of Immunobiology, Yale University School of Medicine, New Haven, United States ruslan.medzhitov@yale.edu.
Yale University · US

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
NCATS NIH HHS UL1 TR000142
6 · The paper itself

Abstract

The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response.

Indexed as

AnimalsDectin-1HumansImmunity, InnateLectins, C-TypeMelanoma, ExperimentalDectin-1Lectins, C-TypecancerDectin-1immunologyinnate immunityIRFmouseNK cell

Identifiers

PMID25250710
PMCPMC4172991
OpenAlexW2138150188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.