Evidence map›Paper›PMID 25250641›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2014

Transmission of methicillin-resistant Staphylococcus aureus via deceased donor liver transplantation confirmed by whole genome sequencing.

D R Altman, R Sebra, J Hand, O Attie, G Deikus, K W D Carpini, G Patel, M Rana, A Arvelakis, P Grewal and 9 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecular concordance of methicillin-resistantInfection control and hospital epidemiology · 2023
    Article
  4. Article
  5. Impact of donor multidrug-resistant organisms on solid organ transplant recipient outcomes.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  6. Article
  7. Article
  8. Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistantProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Genome Plasticity ofInfection and immunity · 2018
    Article
  10. Article
  11. Article
  12. Review
  13. Methicillin-resistantInfection and drug resistance · 2018
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

D R AltmanDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine, New York, NY.
R Sebra
J Hand
O Attie
G Deikus
K W D Carpini
G Patel
M Rana
A Arvelakis
P Grewal
J Dutta
H Rose
B Shopsin
S Daefler
E Schadt
A Kasarskis
H van Bakel
A Bashir
S Huprikar
Icahn School of Medicine at Mount Sinai · USNew York University · USDonor Network West · US

Funding

TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
Role of precipitous virulence in invasiveness of community-acquired methicillin-rR01AI103268 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO, TORRES, VICTOR J. · 2013 to 2017
$2.1M
NIAID NIH HHS 5 T32 AI 7647-13NIAID NIH HHS R01 AI103268NIAID NIH HHS T32 AI007647
6 · The paper itself

Abstract

Donor-derived bacterial infection is a recognized complication of solid organ transplantation (SOT). The present report describes the clinical details and successful outcome in a liver transplant recipient despite transmission of methicillin-resistant Staphylococcus aureus (MRSA) from a deceased donor with MRSA endocarditis and bacteremia. We further describe whole genome sequencing (WGS) and complete de novo assembly of the donor and recipient MRSA isolate genomes, which confirms that both isolates are genetically 100% identical. We propose that similar application of WGS techniques to future investigations of donor bacterial transmission would strengthen the definition of proven bacterial transmission in SOT, particularly in the presence of highly clonal bacteria such as MRSA. WGS will further improve our understanding of the epidemiology of bacterial transmission in SOT and the risk of adverse patient outcomes when it occurs.

Indexed as

Genome, BacterialTissue DonorsAdultCadaverDNA, BacterialFemaleHumansLiver TransplantationMethicillin-Resistant Staphylococcus aureusSequence Analysis, DNAStaphylococcal InfectionsDNA, Bacterial

Identifiers

PMID25250641
PMCPMC4651443
OpenAlexW2127640762

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.