ArticlePloS one2014
Emergence of bursting activity in connected neuronal sub-populations.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Role of connectivity anisotropies in the dynamics of cultured neuronal networks.PLoS computational biology · 2025Article
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- The Profile of Network Spontaneous Activity and Functional Organization Interplay in Hierarchically Connected Modular Neural Networks In Vitro.Micromachines · 2024Article
- Connectivity and network burst properties of in-vitro neuronal networks induced by a clustered structure with alginate hydrogel patterning.Biomedical engineering letters · 2023Article
- Loss of neuron network coherence induced by virus-infected astrocytes: a model study.Scientific reports · 2023Article
- Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics ofFrontiers in neural circuits · 2023Article
- Rich dynamics and functional organization on topographically designed neuronal networksiScience · 2022Article
- Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering.Brain sciences · 2022Review
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- Neurons-on-a-Chip:Molecules and cells · 2022Review
- Flexibility ofFrontiers in cellular neuroscience · 2022Article
- Review
- Spontaneous and Perturbational Complexity in Cortical Cultures.Brain sciences · 2021Article
- Experimental Platform to Study Spiking Pattern Propagation in Modular Networks In Vitro.Brain sciences · 2021Article
- Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology.Micromachines · 2021Review
- Cell-cell coupling and DNA methylation abnormal phenotypes in the after-hours mice.Epigenetics & chromatin · 2021Article
- Thresholding Functional Connectivity Matrices to Recover the Topological Properties of Large-Scale Neuronal Networks.Frontiers in neuroscience · 2021Article
- Thermoplasmonic neural chip platform for in situ manipulation of neuronal connections in vitro.Nature communications · 2020Article
- Canard-induced complex oscillations in an excitatory network.Journal of mathematical biology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Uniform and modular primary hippocampal cultures from embryonic rats were grown on commercially available micro-electrode arrays to investigate network activity with respect to development and integration of different neuronal populations. Modular networks consisting of two confined active and inter-connected sub-populations of neurons were realized by means of bi-compartmental polydimethylsiloxane structures. Spontaneous activity in both uniform and modular cultures was periodically monitored, from three up to eight weeks after plating. Compared to uniform cultures and despite lower cellular density, modular networks interestingly showed higher firing rates at earlier developmental stages, and network-wide firing and bursting statistics were less variable over time. Although globally less correlated than uniform cultures, modular networks exhibited also higher intra-cluster than inter-cluster correlations, thus demonstrating that segregation and integration of activity coexisted in this simple yet powerful in vitro model. Finally, the peculiar synchronized bursting activity shown by confined modular networks preferentially propagated within one of the two compartments ('dominant'), even in cases of perfect balance of firing rate between the two sub-populations. This dominance was generally maintained during the entire monitored developmental frame, thus suggesting that the implementation of this hierarchy arose from early network development.
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