ArticleCPT: pharmacometrics & systems pharmacology2014
Similarity-based modeling applied to signal detection in pharmacovigilance.
Article in CPT: pharmacometrics & systems pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Application of an Integrative Drug Safety Model for Detection of Adverse Drug Events Associated With Inhibition of Glutathione Peroxidase 1 in Chronic Obstructive Pulmonary Disease.Pharmaceutical research · 2023Article
- Considerations and challenges for sex-aware drug repurposing.Biology of sex differences · 2022Review
- Random control selection for conducting high-throughput adverse drug events screening using large-scale longitudinal health data.CPT: pharmacometrics & systems pharmacology · 2021Article
- A compound attributes-based predictive model for drug induced liver injury in humans.PloS one · 2020Article
- Towards early detection of adverse drug reactions: combining pre-clinical drug structures and post-market safety reports.BMC medical informatics and decision making · 2019Article
- Binding site matching in rational drug design: algorithms and applications.Briefings in bioinformatics · 2019Review
- The role of drug profiles as similarity metrics: applications to repurposing, adverse effects detection and drug-drug interactions.Briefings in bioinformatics · 2017Article
- An Interoperable Similarity-based Cohort Identification Method Using the OMOP Common Data Model version 5.0.Journal of healthcare informatics research · 2017Article
- In silico methods for drug repurposing and pharmacology.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Leveraging 3D chemical similarity, target and phenotypic data in the identification of drug-protein and drug-adverse effect associations.Journal of cheminformatics · 2016Article
- A Method to Combine Signals from Spontaneous Reporting Systems and Observational Healthcare Data to Detect Adverse Drug Reactions.Drug safety · 2015Observational
- Integrating Multiple Evidence Sources to Predict Adverse Drug Reactions Based on a Systems Pharmacology Model.CPT: pharmacometrics & systems pharmacology · 2015Article
- Database: A New Article Type in CPT: Pharmacometrics & Systems Pharmacology.CPT: pharmacometrics & systems pharmacology · 2015Article
- 3D pharmacophoric similarity improves multi adverse drug event identification in pharmacovigilance.Scientific reports · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
One of the main objectives in pharmacovigilance is the detection of adverse drug events (ADEs) through mining of healthcare databases, such as electronic health records or administrative claims data. Although different approaches have been shown to be of great value, research is still focusing on the enhancement of signal detection to gain efficiency in further assessment and follow-up. We applied similarity-based modeling techniques, using 2D and 3D molecular structure, ADE, target, and ATC (anatomical therapeutic chemical) similarity measures, to the candidate associations selected previously in a medication-wide association study for four ADE outcomes. Our results showed an improvement in the precision when we ranked the subset of ADE candidates using similarity scorings. This method is simple, useful to strengthen or prioritize signals generated from healthcare databases, and facilitates ADE detection through the identification of the most similar drugs for which ADE information is available.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.