ReviewFrontiers in chemistry2014
Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers.
Review in Frontiers in chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Glycoside Compounds from Blood-Nourishing Chinese Medicinal Herbs: Structural Characteristics, Pharmacological Mechanisms, and Therapeutic Potential for Thrombocytopenia.Molecules (Basel, Switzerland) · 2026Review
- Cytotoxic Triterpene Glycosides from Mexican Sea CucumberJournal of natural products · 2025Article
- Anticancer activity of triterpene glycosides from the sea star Solaster pacificus.Scientific reports · 2025Article
- Cladolosides of Groups S and T: Triterpene Glycosides from the Sea CucumberMarine drugs · 2025Article
- Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators.Marine drugs · 2024Article
- Djakonoviosides A, AInternational journal of molecular sciences · 2023Article
- Chilensosides E, F, and G-New Tetrasulfated Triterpene Glycosides from the Sea CucumberMarine drugs · 2023Article
- The Isolation, Structure Elucidation and Bioactivity Study of Chilensosides A, AMolecules (Basel, Switzerland) · 2022Article
- Novel Triterpenic Acid-Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents.International journal of molecular sciences · 2022Article
- Structures and Biologic Activity of Chitonoidosides I, J, K, KMarine drugs · 2022Article
- Article
- Neurorescue Effects of Frondoside A and Ginsenoside Rg3 inMolecules (Basel, Switzerland) · 2021Article
- Triterpene Glycosides from the Far Eastern Sea CucumberMarine drugs · 2021Article
- Review
- Bitter Melon (Cancers · 2020Review
- Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents.Frontiers in endocrinology · 2020Review
- Frondoside A Attenuates Amyloid-β Proteotoxicity in TransgenicFrontiers in pharmacology · 2020Article
- Medicinal and health benefit effects of functional sea cucumbers.Journal of traditional and complementary medicine · 2018Review
- The Anti-Cancer Effects of Frondoside A.Marine drugs · 2018Review
- Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation.Cell discovery · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune, and other various cells are not fully known. This review focuses on the structural characteristics of marine triterpene glycosides and how these affect their biological activities and molecular mechanisms. In particular, the membranotropic and membranolytic activities of frondoside A and cucumariosides from sea cucumbers and their ability to induce cytotoxicity and apoptosis have been discussed, with a focus on structure-activity relationships. In addition, the structural characteristics and antitumor effects of stichoposide C and stichoposide D have been reviewed along with underlying their molecular mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.