Translation Elongation Rate Measurement of Epstein-Barr Virus Strain GD1.

Gholamreza Motalleb

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Article in Iranian journal of cancer prevention, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 45% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Listeria Monocytogenes La111 and Klebsiella Pneumoniae KCTC 2242: Shine-Dalgarno Sequences.International journal of molecular and cellular medicine · 2014
Article

4 · The record

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5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Gholamreza MotallebDept. of Biology, Faculty of Science, University of Zabol, Zabol, Iran.

Zabol University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpstein-Barr Virus (EBV) has a great co relationship with human malignancies such as gastric carcinoma. Synonymous codon investigations in viruses could help designing vaccine, to generate immunity. Codon Adaptation Index (CAI) has measured translation elongation rate, among the highly expressed genes. The aim of this study was: usage of "CAI" to measure translation efficiency to know how fast EBV-GD1 could produce its proteins.

methodsThe complete genomic sequences of human herpes virus 4 strain GD1 have retrieved from <http://www.ncbi.nlm.nih.gov/sites/gquery> (GenBank accession no. AY961628) to extract all protein-coding genes. The sequences have analyzed with DAMBE software.

resultsThe results have shown that CAI values for the EBV-GD1 genes were 0.76356 ± 0.02957. The highest and lowest CAI values were 0.82233 and 0.68321 respectively. The results have shown that highly expressed genes mostly had more codon usage bias than low expressed genes.

conclusionThe results provide and introduce not only a system, but also the principles in order to understand the pathogenesis and evolution of EBV-GD1, to open a window, in order to make a better product or vaccine to challenge with the virus.

Indexed as

Codon usage biasEpstein-Barr virusGene expression

Identifiers

PMID25250137

PMCPMC4142932

OpenAlexW1880880733

What OpenQuestion holds

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LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.