ReviewFrontiers in endocrinology2014
An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism.
Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 89 citations in OpenAlex.
- Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development.Scientific reports · 2024Article
- The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions.Frontiers in neuroscience · 2024Review
- Iodotyrosines Are Biomarkers for Preclinical Stages of Iodine-Deficient Hypothyroidism inThyroid : official journal of the American Thyroid Association · 2023Article
- Thyroid hormone as a temporal switch in mouse development.European thyroid journal · 2023Review
- Article
- Brain nuclear receptors and cardiovascular function.Cell & bioscience · 2023Review
- Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms.Frontiers in endocrinology · 2023Review
- Congenital Hypothyroidism and Brain Development: Association With Other Psychiatric Disorders.Frontiers in neuroscience · 2021Review
- Reinterpreting patterns of variation in human thyroid function: An evolutionary ecology perspective.Evolution, medicine, and public health · 2021Review
- Regulation of Thyroid-disrupting Chemicals to Protect the Developing Brain.Endocrinology · 2020Review
- A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons.iScience · 2020Article
- Transient Hypothyroidism During Lactation Alters the Development of the Corpus Callosum in Rats. AnFrontiers in neuroanatomy · 2020Article
- Thyroid hormone regulation of neural stem cell fate: From development to ageing.Acta physiologica (Oxford, England) · 2020Review
- Solving for X: Evidence for sex-specific autism biomarkers across multiple transcriptomic studies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Knock-Down of Specific Thyroid Hormone Receptor Isoforms Impairs Body Plan Development in Zebrafish.Frontiers in endocrinology · 2019Article
- Childhood polybrominated diphenyl ether (PBDE) serum concentration and reading ability at ages 5 and 8 years: The HOME Study.Environment international · 2019Article
- Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?Trends in molecular medicine · 2018Review
- Developmental Thyroid Hormone Insufficiency Induces a Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Retinoid receptor-related orphan receptor alpha: a key gene setting brain circuits.Neural regeneration research · 2018Article
- Iodine as Essential Nutrient during the First 1000 Days of Life.Nutrients · 2018Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morphological alterations of cortical lamination observed in mouse models of developmental hypothyroidism prompted the recognition that these experimental changes resembled the brain lesions of children with autism; this led to recent studies showing that maternal thyroid hormone deficiency increases fourfold the risk of autism spectrum disorders (ASD), offering for the first time the possibility of prevention of some forms of ASD. For ethical reasons, the role of thyroid hormones on brain development is currently studied using animal models, usually mice and rats. Although mammals have in common many basic developmental principles regulating brain development, as well as fundamental basic mechanisms that are controlled by similar metabolic pathway activated genes, there are also important differences. For instance, the rodent cerebral cortex is basically a primary cortex, whereas the primary sensory areas in humans account for a very small surface in the cerebral cortex when compared to the associative and frontal areas that are more extensive. Associative and frontal areas in humans are involved in many neurological disorders, including ASD, attention deficit-hyperactive disorder, and dyslexia, among others. Therefore, an evo-devo approach to neocortical evolution among species is fundamental to understand not only the role of thyroid hormones and environmental thyroid disruptors on evolution, development, and organization of the cerebral cortex in mammals but also their role in neurological diseases associated to thyroid dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.