ArticleFrontiers in behavioral neuroscience2014
Depressive-like behavioral response of adult male rhesus monkeys during routine animal husbandry procedure.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Low circulating adropin concentrations identify vulnerability in learning-dependent cognitive performance in aged rhesus macaques.npj aging · 2026Article
- Depression in Mature Male Rhesus Macaques (Macaca mulatta): Direct and Delayed Consequences of Deprivation.Bulletin of experimental biology and medicine · 2026Article
- Inactive but awake behaviour as indicating a depression-like state in mice: aetiological factors and association with adult hippocampal neurogenesis.Royal Society open science · 2025Article
- Insights for the Next Generation of Ketamine for the Treatment of Depressive Disorder.Journal of medicinal chemistry · 2025Review
- An exploration of the postural, location- and social contact- related sub-characteristics of inactive but awake behaviour as a depression-like indicator in mice.Applied animal behaviour science · 2024Article
- Shared Accountability Shaping the Destinies of Individual and Groups of Nonhuman Primates.Veterinary sciences · 2024Article
- An analysis of risk factors for spontaneously occurring type 2 diabetes mellitus in rhesus macaques (Macaca mulatta).Journal of medical primatology · 2024Article
- Cardiac psychophysiological tuning to socioaffective content is disrupted in aged rhesus monkeys (Macaca mulatta).Psychophysiology · 2024Article
- Effects of pair housing on behavior, cortisol, and clinical outcomes during quarantine-like procedures for rhesus macaques (Macaca mulatta).Journal of medical primatology · 2023Article
- Waking inactivity as a welfare indicator in laboratory mice: investigating postures, facial expressions and depression-like states.Royal Society open science · 2022Article
- Nonhuman primate abnormal behavior: Etiology, assessment, and treatment.American journal of primatology · 2022Review
- Social housing status impacts rhesus monkeys' affective responding in classic threat processing tasks.Scientific reports · 2022Article
- Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice.Nature communications · 2022Article
- Recommendations for Abnormal Behaviour Ethograms in Monkey Research.Animals : an open access journal from MDPI · 2021Article
- Learning the Mental Health Impact of COVID-19 in the United States With Explainable Artificial Intelligence: Observational Study.JMIR mental health · 2021Article
- Depression, dementia and immune dysregulation.Brain : a journal of neurology · 2021Article
- Animal Models of Depression: What Can They Teach Us about the Human Disease?Diagnostics (Basel, Switzerland) · 2021Review
- Animal models of human mood.Neuroscience and biobehavioral reviews · 2021Review
- Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress.Frontiers in behavioral neuroscience · 2021Article
- Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques.Frontiers in behavioral neuroscience · 2021Article
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4 authors.
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Abstract
Social isolation is a major risk factor for the development of depressive illness; yet, no practical nonhuman primate model is available for studying processes involved in this effect. In a first study, we noted that adult male rhesus monkeys housed individually indoors occasionally exhibited a hunched, depressive-like posture. Therefore, Study 2 investigated the occurrence of a hunched posture by adult males brought from outdoor social groups to indoor individual housing. We also scored two other behaviors-lying on the substrate and day time sleeping-that convey an impression of depression. During the first week of observation following individual housing, 18 of 26 adult males exhibited the hunched posture and 21 of 26 displayed at least one depressive-like behavior. Over 2 weeks, 23 of 26 males showed depressive-like behavior during a total of only 20 min observation. Further, the behavior during the first week was positively related to the level of initial response to a maternal separation procedure experienced in infancy. In Study 3, more than half of 23 adult males of a new sample displayed depressive-like behavior during 10 min of observation each of Weeks 7-14 of individual housing. The surprisingly high frequency of depressive-like behavior in Studies 2 and 3 may have been due to recording behavior via camera with no human in the room to elicit competing responses. These results suggest that a common animal husbandry procedure might provide a practical means for examining effects of social isolation on depression-related endpoints in a nonhuman primate. The findings also suggest that trait-like differences in emotional responsiveness during separation in infancy may predict differences in responsiveness during social isolation in adulthood.
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