ArticleDose-response : a publication of International Hormesis Society2014
Dissection of the hormetic curve: analysis of components and mechanisms.
Article in Dose-response : a publication of International Hormesis Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Balancing the dual nature of glycotoxins: interplay of diet, digestion, and gut microbiome.Frontiers in nutrition · 2025Review
- 2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism.Biogerontology · 2024Article
- Low-level cadmium exposure induced hormesis in peppermint young plant by constantly activating antioxidant activity based on physiological and transcriptomic analyses.Frontiers in plant science · 2023Article
- Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.Experimental neurology · 2022Article
- Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats.Pharmaceutics · 2020Article
- Isoliquiritigenin Pretreatment Induces Endoplasmic Reticulum Stress-Mediated Hormesis and Attenuates Cisplatin-Induced Oxidative Stress and Damage in LLC-PK1 Cells.Molecules (Basel, Switzerland) · 2020Article
- Environmentally-induced parental or developmental conditioning influences coral offspring ecological performance.Scientific reports · 2020Article
- HSP90 inhibitor PU-H71 increases radiosensitivity of breast cancer cells metastasized to visceral organs and alters the levels of inflammatory mediators.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast.TheScientificWorldJournal · 2020Article
- Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the GenusMarine drugs · 2019Article
- Anti-pathogenic potential of a classicalF1000Research · 2019Article
- Effect of dietary additives on intestinal permeability in bothDisease models & mechanisms · 2018Article
- Behavioral, Biochemical and Molecular Characterization of a Parkinson's Disease Mouse Model Using the Neurotoxin 2'-CHNeuromolecular medicine · 2018Article
- Time-course and intensity-based classifications of oxidative stresses and their potential application in biomedical, comparative and environmental research.Redox report : communications in free radical research · 2016Article
- Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative.Biogerontology · 2015Review
- Carbon Sources for Yeast Growth as a Precondition of Hydrogen Peroxide Induced Hormetic Phenotype.International journal of microbiology · 2015Article
- Hormetic Effect of H2O2 in Saccharomyces cerevisiae: Involvement of TOR and Glutathione Reductase.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between the dose of an effector and the biological response frequently is not described by a linear function and, moreover, in some cases the dose-response relationship may change from positive/adverse to adverse/positive with increasing dose. This complicated relationship is called "hormesis". This paper provides a short analysis of the concept along with a description of used approaches to characterize hormetic relationships. The whole hormetic curve can be divided into three zones: I - a lag-zone where no changes are observed with increasing dose; II - a zone where beneficial/adverse effects are observed, and III - a zone where the effects are opposite to those seen in zone II. Some approaches are proposed to analyze the molecular components involved in the development of the hormetic character of dose-response relationships with the use of specific genetic lines or inhibitors of regulatory pathways. The discussion is then extended to suggest a new parameter (half-width of the hormetic curve at zone II) for quantitative characterization of the hormetic curve. The problems limiting progress in the development of the hormesis concept such as low reproducibility and predictability may be solved, at least partly, by deciphering the molecular mechanisms underlying the hormetic dose-effect relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.