ArticleDiabetes care2014
We can change the natural history of type 2 diabetes.
Article in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05040087 (Changing the Natural History of Type 2 Diabetes), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review.International journal of environmental research and public health · 2018Pooled it
- Effect of Early Time-Restricted Eating on Metabolic Markers and Body Composition in Individuals with Overweight or Obesity.Nutrients · 2024Trial
- Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial.Diabetes care · 2024 · on this mapTrial
- Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial.Scientific reports · 2022Trial
- The effect of photobiomodulation therapy on nonsurgical periodontal treatment in patients with type 2 diabetes mellitus: a randomized controlled, single-blind, split-mouth clinical trial.Lasers in medical science · 2020Trial
- Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease.Diabetes care · 2016Trial
- Undiagnosed pediatric type 2 diabetes mellitus: the giant hidden iceberg.World journal of pediatrics : WJP · 2025Article
- Article
- Relationship between Marriage and Prediabetes among Healthcare Workers: Mediating Effect of Triglycerides.Medicina (Kaunas, Lithuania) · 2024Observational
- Diabetes Management Based on the Phenotype and Stage of the Disease: An Expert Proposal from the AGORA Diabetes Collaborative Group.Journal of clinical medicine · 2024Review
- Fat-to-blood recirculation of partially dysfunctional PD-1iScience · 2024Article
- Metabolic Impact of Frailty Changes Diabetes Trajectory.Metabolites · 2023Review
- Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis.Theranostics · 2023Article
- Waist circumference and dysglycaemia: new insights and additional questions, but do not miss the opportunity to measure it!Internal and emergency medicine · 2022Article
- Serological and Histological Evaluation of the Effect of Honeybee Venom on Pancreas and Liver in Diabetic Mice.Archives of Razi Institute · 2022Article
- Not Control but Conquest: Strategies for the Remission of Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2022Review
- Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults.Cardiovascular diabetology · 2021Article
- The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Evaluating the Evidence behind the Novel Strategy of Early Combination from Vision to Implementation.Diabetes & metabolism journal · 2020Review
- Abscisic Acid Treatment in Patients with Prediabetes.Nutrients · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
As diabetes develops, we currently waste the first ∼10 years of the natural history. If we found prediabetes and early diabetes when they first presented and treated them more effectively, we could prevent or delay the progression of hyperglycemia and the development of complications. Evidence for this comes from trials where lifestyle change and/or glucose-lowering medications decreased progression from prediabetes to diabetes. After withdrawal of these interventions, there was no "catch-up"-cumulative development of diabetes in the previously treated groups remained less than in control subjects. Moreover, achieving normal glucose levels even transiently during the trials was associated with a substantial reduction in subsequent development of diabetes. These findings indicate that we can change the natural history through routine screening to find prediabetes and early diabetes, combined with management aimed to keep glucose levels as close to normal as possible, without hypoglycemia. We should also test the hypothesis with a randomized controlled trial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.