ArticlePlanta2015
Differential regulation of caffeine metabolism in Coffea arabica (Arabica) and Coffea canephora (Robusta).
Article in Planta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 93 citations in OpenAlex.
- Development of a flavour wheel for Coffea canephora using rate-all-that-apply.Scientific reports · 2025Article
- Genome mining of metabolic gene clusters in the Rubiaceae family.Computational and structural biotechnology journal · 2024Article
- Evolution of the biochemistry underpinning purine alkaloid metabolism in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Oral Health and Nutraceutical Agents.International journal of molecular sciences · 2024Review
- Genome-wide analysis and identification of Carotenoid Cleavage Oxygenase (CCO) gene family in coffee (coffee arabica) under abiotic stress.BMC genomic data · 2024Article
- mRNA-miRNA analyses reveal the involvement of CsbHLH1 and miR1446a in the regulation of caffeine biosynthesis inHorticulture research · 2024Article
- The transcription factor CsS40 negatively regulatesHorticulture research · 2023Article
- New cup out of old coffee: contribution of parental gene expression legacy to phenotypic novelty in coffee beans of the allopolyploid Coffea arabica L.Annals of botany · 2023Article
- Global transcriptome profiling reveals differential regulatory, metabolic and hormonal networks during somatic embryogenesis in Coffea arabica.BMC genomics · 2023Article
- Interactive deciphering electron-shuttling characteristics ofIndustrial crops and products · 2023Article
- Comprehensive analysis of quality characteristics in main commercial coffee varieties and wild Arabica in Kenya.Food chemistry: X · 2022Article
- The biological feasibility and social context of gene-edited, caffeine-free coffee.Food science and biotechnology · 2022Review
- Metabolomics Combined with Sensory Analysis Reveals the Impact of Different Extraction Methods on Coffee Beverages fromFoods (Basel, Switzerland) · 2022Article
- Risk Assessment of Caffeine and Epigallocatechin Gallate in Coffee Leaf Tea.Foods (Basel, Switzerland) · 2022Review
- From Plantation to Cup: Changes in Bioactive Compounds during Coffee Processing.Foods (Basel, Switzerland) · 2021Review
- An ancient whole-genome duplication event and its contribution to flavor compounds in the tea plant (Camellia sinensis).Horticulture research · 2021Article
- Decaffeination and Neuraminidase Inhibitory Activity of Arabica Green Coffee (Molecules (Basel, Switzerland) · 2021Article
- Influence of Various Factors on Caffeine Content in Coffee Brews.Foods (Basel, Switzerland) · 2021Review
- The absence of the caffeine synthase gene is involved in the naturally decaffeinated status of Coffea humblotiana, a wild species from Comoro archipelago.Scientific reports · 2021Article
- Coffee Extends Yeast Chronological Lifespan through Antioxidant Properties.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine is a metabolite of great economic importance, especially in coffee, where it influences the sensorial and physiological impacts of the beverage. Caffeine metabolism in the Coffea species begins with the degradation of purine nucleotides through three specific N-methyltransferases: XMT, MXMT and DXMT. A comparative analysis was performed to clarify the molecular reasons behind differences in caffeine accumulation in two Coffea species, namely Coffea arabica and Coffea canephora var. robusta. Three different genes encoding N-methyltransferase were amplified in the doubled haploid Coffea canephora: CcXMT1, CcMXMT1 and CcDXMT. Six genes were amplified in the haploid Coffea arabica: CaXMT1, CaXMT2, CaMXMT1, CaMXMT2, CaDXMT1, and CaDXMT2. A complete phylogenic analysis was performed to identify specific key amino acids defining enzymatic function for each protein identified. Furthermore, a quantitative gene-expression analysis was conducted on leaves and on maturing coffee beans, simultaneously analyzing caffeine content. In the different varieties analyzed, caffeine accumulation is higher in leaves than in the coffee bean maturation period, higher in Robusta than in Arabica. In Robusta, CcXMT1 and CcDXMT gene expressions are predominant and transcriptional activity is higher in leaves than in maturing beans, and is highly correlated to caffeine accumulation. In Arabica, the CaXMT1 expression level is high in leaves and CaDXMT2 as well to a lesser extent, while global transcriptional activity is weak during bean maturation, suggesting that the transcriptional control of caffeine-related genes differs within different organs and between Arabica and Robusta. These findings indicate that caffeine accumulation in Coffea species has been modulated by a combination of differential transcriptional regulation and genome evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.