Trial reportCerebral cortex (New York, N.Y. : 1991)2016
Brain Mechanisms of Social Threat Effects on Working Memory.
Trial report in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analytic evidence for downregulation of the amygdala during working memory maintenance.Human brain mapping · 2022Pooled it
- A Bayesian model of category-specific emotional brain responses.PLoS computational biology · 2015Pooled it
- Prevention of Stress-Provoked Endothelial Injury by Values Affirmation: a Proof of Principle Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Trial
- Forgetting by any other name: The effect of instruction framing on item-method directed forgetting.Quarterly journal of experimental psychology (2006) · 2026Article
- Cortisol and 10-Year Cognitive Decline in Older People From the General Population.European journal of neurology · 2025Article
- Article
- Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Brain mediators of biased social learning of self-perception in social anxiety disorder.Translational psychiatry · 2023Article
- A mesocorticolimbic signature of pleasure in the human brain.Nature human behaviour · 2023Article
- Stress-induced HPA activation in virtual navigation and spatial attention performance.BMC neuroscience · 2022Article
- A multistudy analysis reveals that evoked pain intensity representation is distributed across brain systems.PLoS biology · 2022Article
- Non-human contributions to personality neuroscience - from fish through primates. An introduction to the special issue.Personality neuroscience · 2022Review
- Factors of choking under pressure in musicians.PloS one · 2021Article
- Imaging stress: an overview of stress induction methods in the MR scanner.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Acute psychosocial stress and working memory performance: the potential of physical activity to modulate cognitive functions in children.BMC pediatrics · 2019Observational
- Functional Involvement of Human Periaqueductal Gray and Other Midbrain Nuclei in Cognitive Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Age differences in the neural response to emotional distraction during working memory encoding.Cognitive, affective & behavioral neuroscience · 2018Article
- Representation, Pattern Information, and Brain Signatures: From Neurons to Neuroimaging.Neuron · 2018Review
- Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.Nature neuroscience · 2018Article
- Explicit and implicit emotion regulation: a multi-level framework.Social cognitive and affective neuroscience · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Social threat can have adverse effects on cognitive performance, but the brain mechanisms underlying its effects are poorly understood. We investigated the effects of social evaluative threat on working memory (WM), a core component of many important cognitive capabilities. Social threat impaired WM performance during an N-back task and produced widespread reductions in activation in lateral prefrontal cortex and intraparietal sulcus (IPS), among other regions. In addition, activity in frontal and parietal regions predicted WM performance, and mediation analyses identified regions in the bilateral IPS that mediated the performance-impairing effects of social threat. Social threat also decreased connectivity between the IPS and dorsolateral prefrontal cortex, while increasing connectivity between the IPS and the ventromedial prefrontal cortex, a region strongly implicated in the generation of autonomic and emotional responses. Finally, cortisol response to the stressor did not mediate WM impairment but was rather associated with protective effects. These results provide a basis for understanding interactions between social and cognitive processes at a neural systems level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.