Evidence map›Paper›PMID 25249389›Full record

ArticlePediatric radiology2015

Superficial ultrasound shear wave speed measurements in soft and hard elasticity phantoms: repeatability and reproducibility using two ultrasound systems.

Jonathan R Dillman, Shigao Chen, Matthew S Davenport, Heng Zhao, Matthew W Urban, Pengfei Song, Kuanwong Watcharotone, Paul L Carson

Abstract read
In one paragraph

Article in Pediatric radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

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38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathan R DillmanDepartment of Radiology, Section of Pediatric Radiology, University of Michigan Health System, C. S. Mott Children's Hospital, 1540 E. Hospital Drive, Ann Arbor, MI, 48109, USA, jonadill@med.umich.edu.
Shigao Chen
Matthew S Davenport
Heng Zhao
Matthew W Urban
Pengfei Song
Kuanwong Watcharotone
Paul L Carson

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Nonlinear Ultrasound: an Imaging Biomarker of Intestinal Fibrosis in Crohn's DiseaseR01DK109032 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DILLMAN, JONATHAN RUSSELL, HIGGINS, PETER D.R. · 2016 to 2019
$2.4M
Virtual Biopsy with Ultrasound for Liver Fibrosis StagingR01DK082408 · NIDDK · MAYO CLINIC ROCHESTER · PI CHEN, SHIGAO · 2009 to 2013
$1.6M
NCATS NIH HHS 2UL1TR000433NCATS NIH HHS UL1 TR000433NIDDK NIH HHS DK082408NIDDK NIH HHS R01 DK082408NIDDK NIH HHS R01 DK109032
6 · The paper itself

Abstract

backgroundThere is a paucity of data available regarding the repeatability and reproducibility of superficial shear wave speed (SWS) measurements at imaging depths relevant to the pediatric population.

objectiveTo assess the repeatability and reproducibility of superficial shear wave speed measurements acquired from elasticity phantoms at varying imaging depths using three imaging methods, two US systems and multiple operators. MATERIALS AND

methodsSoft and hard elasticity phantoms manufactured by Computerized Imaging Reference Systems Inc. (Norfolk, VA) were utilized for our investigation. Institution No. 1 used an Acuson S3000 US system (Siemens Medical Solutions USA, Malvern, PA) and three shear wave imaging method/transducer combinations, while institution No. 2 used an Aixplorer US system (SuperSonic Imagine, Bothell, WA) and two different transducers. Ten stiffness measurements were acquired from each phantom at three depths (1.0 cm, 2.5 cm and 4.0 cm) by four operators at each institution. Student's t-test was used to compare SWS measurements between imaging techniques, while SWS measurement agreement was assessed with two-way random effects single-measure intra-class correlation coefficients (ICCs) and coefficients of variation. Mixed model regression analysis determined the effect of predictor variables on SWS measurements.

resultsFor the soft phantom, the average of mean SWS measurements across the various imaging methods and depths was 0.84 ± 0.04 m/s (mean ± standard deviation) for the Acuson S3000 system and 0.90 ± 0.02 m/s for the Aixplorer system (P = 0.003). For the hard phantom, the average of mean SWS measurements across the various imaging methods and depths was 2.14 ± 0.08 m/s for the Acuson S3000 system and 2.07 ± 0.03 m/s Aixplorer system (P > 0.05). The coefficients of variation were low (0.5-6.8%), and interoperator agreement was near-perfect (ICCs ≥ 0.99). Shear wave imaging method and imaging depth significantly affected measured SWS (P < 0.0001).

conclusionSuperficial shear wave speed measurements in elasticity phantoms demonstrate minimal variability across imaging method/transducer combinations, imaging depths and operators. The exact clinical significance of this variation is uncertain and may change according to organ and specific disease state.

Indexed as

Phantoms, ImagingAlgorithmsElasticity Imaging TechniquesElastic ModulusHumansImage Processing, Computer-AssistedReproducibility of ResultsTransducers

Identifiers

PMID25249389
PMCPMC4346477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.