Evidence map›Paper›PMID 25249297›Full record

ArticleJournal of the American Heart Association2014

Circulating microRNAs serve as novel biological markers for intracranial aneurysms.

Pengxiang Li, Qunye Zhang, Xiao Wu, Xinjian Yang, Yun Zhang, Youxiang Li, Fan Jiang

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Epigenetic mechanisms in aneurysm formation, growth, and rupture: A systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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  5. Molecular Targets for Intracranial Aneurysm Treatment.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pengxiang LiKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong Province, China (P.L., Q.Z., X.W., Y.Z., F.J.) Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (P.L., X.Y., Y.L.).
Qunye ZhangKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong Province, China (P.L., Q.Z., X.W., Y.Z., F.J.).
Xiao WuKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong Province, China (P.L., Q.Z., X.W., Y.Z., F.J.).
Xinjian YangBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (P.L., X.Y., Y.L.).
Yun ZhangKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong Province, China (P.L., Q.Z., X.W., Y.Z., F.J.).
Youxiang LiBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (P.L., X.Y., Y.L.).
Fan JiangKey Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong Province, China (P.L., Q.Z., X.W., Y.Z., F.J.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiological markers that can be used to predict the risk of intracranial aneurysms (IAs) are not available. METHODS AND

resultsTo clarify whether circulating microRNAs could be used as biomarkers for IA, we carried out microarray assays in a screening cohort of 40 IA patients (20 unruptured and 20 ruptured) and 20 healthy volunteers. We identified 20 microRNAs that were unanimously changed in both ruptured and unruptured patients. We confirmed 60% of these changed microRNAs by a separate microarray test with an independent validation cohort (n=143 including 93 IA patients). To identify potential biomarkers, we combined the 2 cohorts and performed quantitative real-time polymerase chain reactions for selected target microRNAs. Logistic regression analysis demonstrated that miR-16 and miR-25 were independent factors for IA occurrence (P<0.001). After controlling for age, sex, smoking, and history of hypertension, the contributions of miR-16 and miR-25 were still highly significant (P<0.001). The adjusted odds ratio values for miR-16 and miR-25 were 1.52 (95% CI 1.31 to 1.77) and 1.53 (1.30 to 1.79). Combining both miR-16 and miR-25 in a single model did not improve the performance of risk association.

conclusionsOur data suggest that circulating miRNAs may be novel biological markers that are useful in assessing the likelihood of IA occurrence.

Indexed as

AdultAneurysm, RupturedCase-Control StudiesFemaleGene Expression ProfilingGenetic MarkersHumansIntracranial AneurysmLogistic ModelsMaleMicroRNAsMiddle AgedOdds RatioOligonucleotide Array Sequence AnalysisPredictive Value of TestsReal-Time Polymerase Chain ReactionGenetic MarkersMicroRNAsMIRN16 microRNA, humanMIRN25 microRNA, humanbiomarkerintracranial aneurysmlogistic regressionmicroRNAplasmarisk factor

Identifiers

PMID25249297
PMCPMC4323791

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.