ReviewProtein & cell2015
The hierarchy quorum sensing network in Pseudomonas aeruginosa.
Review in Protein & cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 652 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
652 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,296 citations in OpenAlex.
- In Silico Approaches Targeting Quorum-Sensing Inhibition inMolecules (Basel, Switzerland) · 2026Pooled it
- Exploring the spatial distribution of biomolecules inBiofilm · 2026Article
- Coordination of quorum sensing with T3SS and T6SS: Bacterial strategies for combating fungal pathogens.Virulence · 2026Review
- Biochemical and molecular insights into the antibiofilm and antivirulence effects of a B-phycoerythrin-rich extract from Porphyridium cruentum against Pseudomonas aeruginosa.Biodegradation · 2026Article
- A Hierarchical OhrR-EmrR Regulatory Circuit Fine-Tunes the Vfm Quorum- Sensing System and Virulence in Dickeya oryzae.Molecular plant pathology · 2026Article
- Smaller Genomes and Shorter Prophage Sequences Differentiate Clinical from Environmental Isolates ofbioRxiv : the preprint server for biology · 2026Article
- Temperature-dependent reprogramming of virulence traits duringbioRxiv : the preprint server for biology · 2026Article
- Natural Lactone-Based Quorum Sensing Inhibitors Attenuate Virulence in Pseudomonas aeruginosa.Chemistry & biodiversity · 2026Article
- Interaction of the polar localization protein BscR with phosphodiesterase PipA regulates virulence strategies in Pseudomonas aeruginosa.Journal of advanced research · 2026Article
- Modified experimental protocol to support the study of bacterial quorum sensing in higher education: an investigative activity withJournal of microbiology & biology education · 2026Article
- Biofilm state transitions: quorum sensing inhibition and network destabilization.Applied microbiology and biotechnology · 2026Review
- Beyond probiotics: Lacticaseibacillus rhamnosus as a multi-target antagonist of Pseudomonas aeruginosa infections.Folia microbiologica · 2026Review
- 400 nm femtosecond laser irradiation eradicates mature MRSA biofilms and inhibits their formation via quorum sensing dysregulation.Scientific reports · 2026Article
- Disarming Pseudomonas aeruginosa: repurposing vardenafil, valsartan, and olmesartan as anti-virulence and antibiofilm agents.Scientific reports · 2026Article
- Article
- Deciphering microbial biofilm: mechanism, infection, and advanced approaches for control.Folia microbiologica · 2026Review
- Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.Chemical Society reviews · 2026Review
- Beyond Resistance Genes:Life (Basel, Switzerland) · 2026Review
- Gramine disrupts quorum sensing and biofilm formation of Pseudomonas aeruginosa: An integrated experimental and computational analysis.Folia microbiologica · 2026Article
- Unveiling the Role of Pseudomonas aeruginosa Quorum Sensing Inhibitors: The Road So Far.Chemical record (New York, N.Y.) · 2026Review
592 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of the pathogen to form biofilm matrix, which provides bacterial cells a protected environment withstanding various stresses including antibiotics. Quorum sensing (QS), a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection. The QS network of P. aeruginosa is organized in a multi-layered hierarchy consisting of at least four interconnected signaling mechanisms. Evidence is accumulating that the QS regulatory network not only responds to bacterial population changes but also could react to environmental stress cues. This plasticity should be taken into consideration during exploration and development of anti-QS therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.