SynthesisHuman molecular genetics2015
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Human molecular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 6 pooled it
11.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 6 syntheses or guidelines pooled it, 204 citations in OpenAlex.
- Pooled it
- The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Genome-wide association study of dermatophytosis in the UK Biobank cohort.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Pooled it
- Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2018Guideline
- Multi-ethnic genome-wide association study for atrial fibrillation.Nature genetics · 2018Pooled it
- Genetic Variation in Steroid and Xenobiotic Metabolizing Pathways and Enterolactone Excretion Before and After Flaxseed Intervention in African American and European American Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Trial
- Common variants in the Na(+)-coupled bicarbonate transporter genes and salt sensitivity of blood pressure: the GenSalt study.Journal of human hypertension · 2016Trial
- Molecular systems, human noncoding sequence variants, and blood pressure.Physiological reviews · 2026Review
- Article
- A Genetic Risk Prediction Model for Coronary Artery Disease Integrating CYP17A1 Polymorphisms and Clinical Variables in a Chinese Population.International journal of general medicine · 2026Article
- Review
- Community based cohort studies in China: critical insights for shaping the future of population and public health.BMJ (Clinical research ed.) · 2025Article
- SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy.Animal models and experimental medicine · 2025Article
- Intersecting transcriptomic landscapes of hypertension and kidney function in African American women.American journal of physiology. Renal physiology · 2025Article
- Clinical and genetic markers of vascular toxicity in glioblastoma patients: Insights from NRG Oncology RTOG-0825.Neuro-oncology · 2025Article
- Relationship between HECTD4 gene variants, obesity, and coffee consumption.European journal of clinical nutrition · 2025Article
- Blood Pressure Levels During Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study and Mendelian Randomization Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Causal associations between inflammatory cytokines and hypertensive disorders.Clinical hypertension · 2025Article
- The Genetic Variants Influencing Hypertension Prevalence Based on the Risk of Insulin Resistance as Assessed Using the Metabolic Score for Insulin Resistance (METS-IR).International journal of molecular sciences · 2024Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors at 20 institutions in 2 countries.
Xiangfeng LuState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Laiyuan WangState Key Laboratory of Cardiovascular Disease National Human Genome Center at Beijing, Beijing 100176, China.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
Jianfeng HuangHypertension Division Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Meian HeMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab for Modern Toxicology School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Jingwen ZhuKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
Huaixing LiKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
James E HixsonDepartment of Epidemiology, University of Texas School of Public Health, Houston, TX 77025, USA.
Tangchun WuMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Juncheng DaiDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab for Modern Toxicology School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Ling LuKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
Chong ShenDepartment of Epidemiology and Biostatistics, Ministry of Education Key Lab for Modern Toxicology School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Shufeng ChenState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Lin HeBio-X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai 200030, China.
Zengnan MoCenter for Genomic and Personalized Medicine, Medical Scientific Research Center and Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
Yongchen HaoState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Xingbo MoState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Xueli YangState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Jianxin LiState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Jie CaoState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Jichun ChenState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Zhongjie FanDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Ying LiState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Liancheng ZhaoState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Hongfan LiNational Human Genome Center at Beijing, Beijing 100176, China.
Fanghong LuCardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
Cailiang YaoSchool of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Lin YuDepartment of Cardiology, Fujian Provincial People's Hospital, Fuzhou, Fujian 350004, China.
Lihua XuDepartment of Cardiology, Affiliated Hospital of Beihua University, Beihua University, Jilin 132011, China.
Jianjun MuDepartment of Cardiology, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shannxi 710061, China.
Xianping WuCenter for Chronic and Noncommunicable Disease Control and Prevention, Sichuan Center of Disease Control and Prevention, Chengdu, Sichuan 610041, China.
Ying DengCenter for Chronic and Noncommunicable Disease Control and Prevention, Sichuan Center of Disease Control and Prevention, Chengdu, Sichuan 610041, China.
Dongsheng HuSchool of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China School of Medicine, Shenzhen University, Shenzhen, Guangdong 518000, China.
Weidong ZhangSchool of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China.
Xu JiDepartment of Internal Medicine, Xinle Red Cross Hospital, Xinle, Hebei 050700, China.
Dongshuang GuoDepartment of Internal Medicine, Yuxian Renmin Hospital, Yuxian, Shanxi 045100, China.
Zhirong GuoDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, China.
Zhengyuan ZhouChangshu Center of Disease Control and Prevention, Changshu, Jiangsu 215501, China.
Zili YangNantong Center of Disease Control and Prevention, Nantong, Jiangsu 226007, China.
Renping WangDepartment of Internal Medicine, Shijiazhuang Greatwall Hospital, Shijiazhuang, Hebei 052260, China.
Jun YangDepartment of Cardiology, Hanzhong People's Hospital, Hanzhong, Shannxi 723000, China.
Xiaoyang ZhouDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Weili YanDepartment of Clinical Epidemiology, Children's Hospital of Fudan University, Shanghai 200062, China.
Ningling SunDepartment of Heart Center, Peking University People's Hospital, Beijing 100044, China and.
Pingjin GaoState Key Laboratory of Medical Genetics, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Dongfeng GuState Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China gudongfeng@vip.sina.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNState Key Laboratory of Cardiovascular DiseaseNanjing Medical University · CNChinese Academy of Sciences · CNChinese National Human Genome Center · CNHuazhong University of Science and Technology · CNShanghai Institutes for Biological Sciences · CNShanghai Jiao Tong University · CNSichuan Center for Disease Control and Prevention · CNZhengzhou University · CNBeihua University · CNChildren's Hospital of Fudan University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNFujian Provincial People's Hospital · CNGuangxi Medical University · CNHanzhong People's Hospital · CNPeking Union Medical College Hospital · CNPeking University People's Hospital · CNQinghai Red Cross Hospital · CNShandong First Medical University · CN
Funding
Genetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6MFamily-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureR01HL090682 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2008 to 2011
$2.8MSodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8MResearch Training in Gene-Environment Interaction in ChinaD43TW009107 · FIC · TULANE UNIVERSITY OF LOUISIANA · PI GU, DONGFENG, HE, JIANG · 2012 to 2016
$1.1MFIC NIH HHS D43 TW009107NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01HL090682NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01HL072507
Abstract
Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified genome-wide significant (P < 5.0 × 10(-8)) associations with blood pressure, which included variants at three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. We also replicated 14 previously reported loci, 8 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 × 10(-3) to 5.16 × 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments.
Indexed as
AdultAgedAsian PeopleBlood PressureCalcium Channels, L-TypeChinaFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypertensionMaleMediator ComplexMiddle AgedPolymorphism, Single NucleotideCACNA1D protein, humanCalcium Channels, L-TypeCYP21A2 protein, humanMED13L protein, humanMediator ComplexSLC4A7 protein, humanSodium-Bicarbonate SymportersSteroid 21-Hydroxylase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.