ArticleThe Journal of antibiotics2015
Sorbicillinoid analogs with cytotoxic and selective anti-Aspergillus activities from Scytalidium album.
Article in The Journal of antibiotics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Phylogenetic assessment and taxonomic revision ofIMA fungus · 2025Article
- Identification of two phthalide derivatives and an oxindole compound isolated from the edible mushroomJournal of pesticide science · 2023Article
- In Vitro Efficacy of Extracts and Isolated Bioactive Compounds from Ascomycota Fungi in the Treatment of Colorectal Cancer: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds.Antibiotics (Basel, Switzerland) · 2022Review
- Homoisoflavonoids from the bulbs of Bellevalia longipes and an assessment of their potential cytotoxic activity.Phytochemistry · 2022Article
- Sorbicillinoid Derivatives with the Radical Scavenging Activities from the Marine-Derived FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Samarium(ii) iodide-mediated reactions applied to natural product total synthesis.RSC advances · 2022Review
- Review
- Coumarins, dihydroisocoumarins, a dibenzo-Tetrahedron letters · 2021Article
- Influences of genetically perturbing synthesis of the typical yellow pigment on conidiation, cell wall integrity, stress tolerance, and cellulase production in Trichoderma reesei.Journal of microbiology (Seoul, Korea) · 2021Article
- Article
- Sorbicillinoid Derivatives From Sponge-Derived FungusFrontiers in microbiology · 2020Article
- Diverse subterranean fungi of an underground iron ore mine.PloS one · 2020Article
- Sorbicillinoid-Based Metabolites from a Sponge-Derived FungusMarine drugs · 2018Article
- Cytotoxic homoisoflavonoids from the bulbs of Bellevalia flexuosa.Fitoterapia · 2018Article
- qNMR for profiling the production of fungal secondary metabolites.Magnetic resonance in chemistry : MRC · 2017Article
- Chemoinformatic expedition of the chemical space of fungal products.Future medicinal chemistry · 2016Article
- Sorbicillinoids from Fungi and Their Bioactivities.Molecules (Basel, Switzerland) · 2016Review
- Cytotoxic Homoisoflavones from the Bulbs of Bellevalia eigii.Journal of natural products · 2015Article
- Biosynthetically Distinct Cytotoxic Polyketides fromEuropean journal of organic chemistry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
As part of an ongoing project to explore filamentous fungi for anticancer and antibiotic leads, 11 compounds were isolated and identified from an organic extract of the fungus Scytalidium album (MSX51631) using bioactivity-directed fractionation against human cancer cell lines. Of these, eight compounds were a series of sorbicillinoid analogs (1-8), of which four were new (scalbucillin A (2), scalbucillin B (3), scalbucillin C (6) and scalbucillin D (8)), two were phthalides (9-10) and one was naphthalenone (11). Compounds (1-11) were tested in the MDA-MB-435 (melanoma) and SW-620 (colon) cancer cell lines. Compound 1 was the most potent with IC50 values of 1.5 and 0.5 μM, followed by compound 5 with IC50 values of 2.3 and 2.5 μM at 72 h. Compound 1 showed a 48-h IC50 value of 3.1 μM when tested against the lymphocytic leukemia cell line OSU-CLL, while the nearly identical compound 5 had almost no activity in this assay. Compounds 1 and 5 showed selective and equipotent activity against Aspergillus niger with minimum IC values of 0.05 and 0.04 μg ml(-1) (0.20 and 0.16 μM), respectively. The in vitro hemolytic activity against sheep erythrocytes of compounds 1 and 5 was investigated and were found to provoke 10% hemolysis at 52.5 and 45.0 μg ml(-1), respectively, indicative of a promising safety factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.