ArticleReproductive biology and endocrinology : RB&E2014
Endometrial gene expression reveals compromised progesterone signaling in women refractory to embryo implantation.
Article in Reproductive biology and endocrinology : RB&E, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Placental dysfunction reflects endocrine impairment and trophoblast alterations in polycystic ovarian syndrome.Scientific reports · 2026Article
- Enrichment of cell cycle pathways in progesterone-treated endometrial organoids of infertile women compared to fertile women.Journal of assisted reproduction and genetics · 2024Article
- The endometrial transcriptome of infertile women with and without implantation failure.Acta obstetricia et gynecologica Scandinavica · 2024Article
- An unbiased approach of molecular characterization of the endometrium: toward defining endometrial-based infertility.Human reproduction (Oxford, England) · 2024Article
- Identification of Potentially Novel Molecular Targets of Endometrial Cancer Using a Non-Biased Proteomic Approach.Cancers · 2023Article
- Article
- The impact of accurately timed mid-luteal endometrial injury in nulligravid women undergoing their first or second embryo transfer.Irish journal of medical science · 2021Article
- Predictive factors for successful pregnancy in an egg-sharing donation program.JBRA assisted reproduction · 2020Article
- An assessment of the multifactorial profile of steroid-metabolizing enzymes and steroid receptors in the eutopic endometrium during moderate to severe ovarian endometriosis.Reproductive biology and endocrinology : RB&E · 2019Article
- Development and utilization of human decidualization reporter cell line uncovers new modulators of female fertility.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Potential Marker Pathways in the Endometrium That May Cause Recurrent Implantation Failure.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases.Clinical epigenetics · 2019Article
- SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.Nature communications · 2018Article
- Article
- Maternal selenium-supplementation at various stages of periconception period: influence on murine blastocyst morphology and implantation status.Journal of animal science and technology · 2017Article
- Gene profiling the window of implantation: Microarray analyses from human and rodent models.Journal of reproductive health and medicine · 2016Article
- Article
- Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity.Journal of pregnancy · 2016Review
- Progesterone administration for luteal phase deficiency in human reproduction: an old or new issue?Journal of ovarian research · 2015Review
- Progesterone in Peri- and Postmenopause: A Review.Geburtshilfe und Frauenheilkunde · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometrial function is essential for embryo implantation. The aim of this study was to analyze gene expression profiles from individual endometrial samples obtained from women with repeated implantation failure after IVF in oocyte donation programs.
methodsSeventeen volunteers were recruited: women who had previously participated as recipients in oocyte donation cycles and repeatedly exhibited implantation failure (Group A, study group, n = 5) or had at least one successful cycle (Group B, control group, n = 6) and spontaneously fertile women (Group C, normal fertility group, n = 6). An endometrial cycle was induced with exogenous estradiol (E2) and progesterone (P) and an endometrial sample was collected on the seventh day of P treatment.
resultsTranscriptome analysis showed 82 genes with consistent differential gene expression when comparing A vs. B and A vs. C. One hundred transcripts differentially expressed in group A vs. B have been shown to be regulated by P, suggesting compromised P signaling in the endometrium. The P receptor (PR) mutation PROGINS was not detected in women from group A. Semi-quantitation of immunoreactive PRA/B, PRB and Sp1 (a transcription factor related to P signaling) in paraffin-embedded endometrial sections, did not show statistically significant differences amongst groups. However immunostaining glycodelin was significantly decreased in endometrial samples from group A.
conclusionsWe conclude that some cases of repeated implantation failure could be associated with an aberrant gene expression profile. Compromised P signaling might be the underlying mechanism for such endometrial gene expression deregulation in women with repeated implantation failure.
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