Trial reportAsian journal of andrology
Late-onset hypogonadism: beyond testosterone.
Trial report in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- The effects of Vitamin D3 supplementation on Spermatogram and endocrine factors in asthenozoospermia infertile men: a randomized, triple blind, placebo-controlled clinical trial.Reproductive biology and endocrinology : RB&E · 2021Trial
- Efficacy and Safety of Ginseng Berry Extract (SIRTBERRY™) in Treating Andropause Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.The world journal of men's health · 2026Article
- Functional hypogonadism among patients with obesity, diabetes, and metabolic syndrome.International journal of impotence research · 2022Review
- Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.Aging clinical and experimental research · 2022Review
- Is Chronic Varicocele a Risk Factor for Secondary Hyperparathyroidism?Journal of clinical medicine · 2022Article
- Article
- Inverse association between serum bilirubin level and testosterone deficiency in middle-aged and older men.Scientific reports · 2021Article
- Effectiveness of a Very Low Calorie Ketogenic Diet on Testicular Function in Overweight/Obese Men.Nutrients · 2020Article
- Vitamin D and Male Fertility: An Updated Review.The world journal of men's health · 2020Review
- Symptomatic late-onset hypogonadism but normal total testosterone: the importance of testosterone annual decrease velocity.Annals of translational medicine · 2020Article
- Fertility Outcomes and Sperm-DNA Parameters in Metastatic Melanoma Survivors Receiving Vemurafenib or Dabrafenib Therapy: Case Report.Frontiers in oncology · 2020Article
- Prevalence of Age-Associated Testosterone Deficiency Syndrome in Indian Population.Advances in urology · 2019Article
- Vitamin D, PCOS and androgens in men: a systematic review.Endocrine connections · 2018Review
- Increased risk of testis failure in testicular germ cell tumor survivors undergoing radiotherapy.Oncotarget · 2018Article
- Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle.Frontiers in endocrinology · 2018Article
- The role of vitamin D in male fertility: A focus on the testis.Reviews in endocrine & metabolic disorders · 2017Review
- Occurrence, patterns & predictors of hypogonadism in patients with HIV infection in India.The Indian journal of medical research · 2017Article
- The role of vitamin D supplementation on erectile function.Turkish journal of urology · 2017Review
- Role of vitamin D levels and vitamin D supplementation on bone mineral density in Klinefelter syndrome.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Commentary on "Late-onset hypogonadism - beyond testosterone".Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-onset hypogonadism is defined as a combination of low testosterone (T) levels and typical symptoms and signs. A major area of uncertainty is whether T concentrations are always really sufficient to fully reflect Leydig cell (dys)function. Mild testicular alteration could be diagnosed only by additional biochemical markers, such as luteinizing hormone (LH) and 25-hydroxyvitamin D levels. These markers help in identifying the so-called "subclinical" hypogonadism (normal T, high LH levels). Patients with hypogonadism have frequently low levels of 25-hydroxyvitamin D due to impairment of the hydroxylating enzyme CYP2R1 in the testis. However, no data have been published dealing with the best treatment option (cholecalciferol - the Vitamin D precursor, or calcidiol - 25-hydroxylated form of Vitamin D) in these patients. We studied 66 patients with classic hypogonadism (total T [TT] <12 nmol l-1 , LH ≥ 8 IU l-1 ) (n = 26) and subclinical hypogonadism (TT ≥ 12 nmol l-1 , LH ≥ 8 IU l-1 ) (n = 40) and low 25-hydroxyvitamin D (<50 nmol l-1 ). Subjects received cholecalciferol (5000 IU per week) (n = 20) or calcidiol (4000 IU per week) (n = 46), and 25-hydroxyvitamin D and parathyroid hormone (PTH) were evaluated after 3 months of therapy. Supplementation with calcidiol significantly increased 25-hydroxyvitamin D and significantly decreased PTH levels in both groups of men with hypogonadism (primary, n = 16 and subclinical, n = 30), whereas supplementation with cholecalciferol did not modify their levels. This study shows for the first time that the administration of the 25-hydroxylated form of Vitamin D (calcidiol), and not the administration of the precursor cholecalciferol, restores 25-hydroxyvitamin D levels in subjects with hypogonadism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.