Evidence map›Paper›PMID 25248648›Full record

Trial reportBritish journal of anaesthesia2015

A randomized, triple-masked, active-controlled investigation of the relative effects of dose, concentration, and infusion rate for continuous popliteal-sciatic nerve blocks in volunteers.

S J Madison, A M Monahan, R R Agarwal, T J Furnish, E J Mascha, Z Xu, M C Donohue, A C Morgan, B M Ilfeld

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01898689 (Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01898689 phase4completednot on this map

Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks

TypeinterventionalSponsorUniversity of California, San DiegoRan2013 to 2013Enrolled24ConditionsRelatively Healthy VolunteersArmsRopivacaine 0.1%, Ropivacaine 0.4%
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

S J MadisonDepartment of Anesthesiology, University of California San Diego, 200 West Arbor Drive, MC 8770, San Diego, CA 92103-8770, USA.
A M MonahanDepartment of Anesthesiology, University of California San Diego, 200 West Arbor Drive, MC 8770, San Diego, CA 92103-8770, USA.
R R AgarwalDepartment of Anesthesiology, University of California San Diego, 200 West Arbor Drive, MC 8770, San Diego, CA 92103-8770, USA.
T J FurnishDepartment of Anesthesiology, University of California San Diego, 200 West Arbor Drive, MC 8770, San Diego, CA 92103-8770, USA.
E J MaschaDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA Department of Outcomes Research, Cleveland Clinic, Cleveland, OH, USA.
Z XuDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA Department of Outcomes Research, Cleveland Clinic, Cleveland, OH, USA.
M C DonohueDivision of Biostatistics and Bioinformatics, University of California San Diego, 200 West Arbor Drive, MC 8770, San Diego, CA 92103-8770, USA.
A C MorganDepartment of Anesthesiology, University of California San Diego, 200 West Arbor Drive, MC 8770, San Diego, CA 92103-8770, USA.
B M IlfeldDepartment of Anesthesiology, University of California San Diego, 200 West Arbor Drive, MC 8770, San Diego, CA 92103-8770, USA bilfeld@ucsd.edu.

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
NCRR NIH HHS UL1RR031980
6 · The paper itself

Abstract

backgroundIt remains unknown whether local anaesthetic dose is the only factor influencing continuous popliteal-sciatic nerve block effects, or whether concentration, volume, or both exert an influence as well.

methodsBilateral sciatic catheters were inserted in volunteers (n=24). Catheters were randomly assigned to ropivacaine of either 0.1% (8 ml h(-1)) or 0.4% (2 ml h(-1)) for 6 h. The primary endpoint was the tolerance to transcutaneous electrical stimulation within the tibial nerve distribution at hour 6. Secondary endpoints included current tolerance at other time points and plantar flexion maximum voluntary isometric contraction (22 h total).

resultsAt hour 6, tolerance to cutaneous stimulation for limbs receiving 0.1% ropivacaine was [mean (standard deviation)] 27.0 (20.2) vs26.9 (20.4) mA for limbs receiving 0.4% [estimated mean difference 0.2 mA; 90% confidence interval (CI) -8.2 to 8.5; P=0.02 and 0.03 for lower and upper boundaries, respectively]. Because the 90% CI fell within the prespecified tolerance ±10 mA, we conclude that the effect of the two concentration/volume combinations were equivalent. Similar negative findings were found for the secondary outcomes.

conclusionsFor continuous popliteal-sciatic nerve blocks, we found no evidence that local anaesthetic concentration and volume influence block characteristics, suggesting that local anaesthetic dose (mass) is the primary determinant of perineural infusion effects in this anatomic location. These findings suggest that for ambulatory perineural local anaesthetic infusion-for which there is usually a finite local anaesthetic reservoir-decreasing the basal rate while increasing the local anaesthetic concentration may allow for increased infusion duration without compromising postoperative analgesia. CLINICAL

trial registrationNCT01898689.

Indexed as

AdultAmidesAnesthesia, LocalAnesthetics, LocalDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansInfusion PumpsMaleMiddle AgedNerve BlockPain MeasurementRopivacaineSciatic NerveYoung AdultAmidesAnesthetics, LocalRopivacainecontinuous peripheral nerve blockperineural infusionperineural local anaesthetic infusion

Identifiers

PMID25248648
PMCPMC4263082

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.