ArticleMolecular genetics and genomics : MGG2015
Identification of copy number variations in Qinchuan cattle using BovineHD Genotyping Beadchip array.
Article in Molecular genetics and genomics : MGG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Copy Number Variation Discovery in South African Nguni-Sired and Bonsmara-Sired Crossbred Cattle.Animals : an open access journal from MDPI · 2023Article
- Towards the detection of copy number variation from single sperm sequencing in cattle.BMC genomics · 2022Article
- Genome-wide analysis of CNVs in three populations of Tibetan sheep using whole-genome resequencing.Frontiers in genetics · 2022Article
- Genome-wide detection of copy number variations in polled yak using the Illumina BovineHD BeadChip.BMC genomics · 2019Article
- Population Structure, and Selection Signatures Underlying High-Altitude Adaptation Inferred From Genome-Wide Copy Number Variations in Chinese Indigenous Cattle.Frontiers in genetics · 2019Article
- Misidentification of runs of homozygosity islands in cattle caused by interference with copy number variation or large intermarker distances.Genetics, selection, evolution : GSE · 2018Article
- Landscape of copy number variations in Bos taurus: individual - and inter-breed variability.BMC genomics · 2018Article
- Association study between copy number variation and beef fatty acid profile of Nellore cattle.Journal of applied genetics · 2018Article
- Yak IGF2 Promotes Fibroblast Proliferation Via Suppression of IGF1R and PI3KCG Expression.Genes · 2018Article
- Genetic Diversity of Seven Cattle Breeds Inferred Using Copy Number Variations.Frontiers in genetics · 2018Article
- Genome-wide analysis reveals differential selection involved with copy number variation in diverse Chinese Cattle.Scientific reports · 2017Article
- Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle.BMC genomics · 2017Article
- Distribution and Functionality of Copy Number Variation across European Cattle Populations.Frontiers in genetics · 2017Article
- Comparative analyses across cattle genders and breeds reveal the pitfalls caused by false positive and lineage-differential copy number variations.Scientific reports · 2016Article
- Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays.Scientific reports · 2016Article
- Genome-wide identification of copy number variation using high-density single-nucleotide polymorphism array in Japanese Black cattle.BMC genetics · 2016Article
- Genome-Wide Study of Structural Variants in Bovine Holstein, Montbéliarde and Normande Dairy Breeds.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, copy number variations (CNVs), which associate with complex traits such as disease and quantitative phenotypes, are increasingly recognized as an important and abundant source of genetic variation and phenotypic diversity. CNVs have been studied in several breeds of cattle with the goal of improving selection methods for commercial use; however, little is known about the extent to which CNVs contribute to genetic variation in Qinchuan cattle. The BovineHD Genotyping BeadChip array was used for analyzing the whole genomic CNVs of Qinchuan cattle breed; we discovered 367 unique CNV events from 6 Qinchuan cattle. Accounting for overlapping regions, a total of 365 autosomal copy number variation regions (CNVRs) (131 losses and 234 gains) were identified with an average number of 60.8 CNV events per individual, which covered 13.13 Mb of the cattle genomic sequence corresponding to 0.4 % of the whole cattle genome. The average and median sizes of CNVRs were 35.07 and 18.56 kb, respectively. The CNVRs map of Qinchuan cattle was first constructed based on the BovineHD Genotyping Beadchip array. Functional analysis indicated that most genes in CNVRs that were significantly enriched are involved in environmental stress. Comparison of CNVRs in ten published studies and the 365 CNVRs identified in our study overlapped 0.7-42.7 %. These findings are the first report of CNVs mapping in Qinchuan cattle and contribute to the greater understanding of CNV genetics in commercial cattle phenotypes.
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