Evidence map›Paper›PMID 25248607›Full record

ArticleNeurobiology of aging2015

Physical activity, body mass index, and brain atrophy in Alzheimer's disease.

Christina P Boyle, Cyrus A Raji, Kirk I Erickson, Oscar L Lopez, James T Becker, H Michael Gach, W T Longstreth, Leonid Teverovskiy, Lewis H Kuller, Owen T Carmichael and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  17. Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Christina P Boyle *Imaging Genetics Center, and Departments of Neurology, Psychiatry, Pediatrics, Engineering, Radiology, and Ophthalmology, Keck USC School of Medicine, University of Southern California, Los Angeles, CA.
Cyrus A Raji *Imaging Genetics Center, and Departments of Neurology, Psychiatry, Pediatrics, Engineering, Radiology, and Ophthalmology, Keck USC School of Medicine, University of Southern California, Los Angeles, CA.
Kirk I EricksonDepartment of Psychology University of Pittsburgh School of Medicine, Pittsburgh, PA.
Oscar L LopezDepartment of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA.
James T BeckerDepartment of Psychology University of Pittsburgh School of Medicine, Pittsburgh, PA.
H Michael GachDepartment of Radiology at University of Pittsburgh School of Medicine, Pittsburgh, PA.
W T LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, WA.
Leonid TeverovskiyDepartment of Psychology University of Pittsburgh School of Medicine, Pittsburgh, PA.
Lewis H KullerDepartment of Epidemiology at the University of Pittsburgh Graduate School of Public Health at Pittsburgh, PA.
Owen T CarmichaelDepartment of Neurology at University of California at Davis, CA.
Paul M ThompsonImaging Genetics Center, and Departments of Neurology, Psychiatry, Pediatrics, Engineering, Radiology, and Ophthalmology, Keck USC School of Medicine, University of Southern California, Los Angeles, CA.
University of Pittsburgh · USUniversity of Southern California · USImaging Center · USUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Predictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7M
Growth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
A Multidimensional Alzheimer's Disease Brain AtlasR01EB008281 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.4M
Predictors of Alzheimers Disease in Mild Cognitive ImpairmentR56AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2007 to 2007
$482k
CHS-ULTRASOUND READINGN01HC045133 · HC · GEISINGER HEALTH SYSTEM · PI O'LEARY, DANIEL H. · 1994 to 2000
$155k
CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
–
NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01-HC-055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-75150NHLBI NIH HHS N01-HC-80007NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS R01 HL080295NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS AG020098NIA NIH HHS AG05133NIA NIH HHS AG15928NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG040060NIA NIH HHS R56 AG020098NIA NIH HHS RF1 AG041915NIBIB NIH HHS EB008281NIBIB NIH HHS R01 EB008281NIBIB NIH HHS U54 EB020403
6 · The paper itself

Abstract

The purpose of this study was to use a novel imaging biomarker to assess associations between physical activity (PA), body mass index (BMI), and brain structure in normal aging, mild cognitive impairment, and Alzheimer's dementia. We studied 963 participants (mean age: 74.1 ± 4.4 years) from the multisite Cardiovascular Health Study including healthy controls (n = 724), Alzheimer's dementia patients (n = 104), and people with mild cognitive impairment (n = 135). Volumetric brain images were processed using tensor-based morphometry to analyze regional brain volumes. We regressed the local brain tissue volume on reported PA and computed BMI, and performed conjunction analyses using both variables. Covariates included age, sex, and study site. PA was independently associated with greater whole brain and regional brain volumes and reduced ventricular dilation. People with higher BMI had lower whole brain and regional brain volumes. A PA-BMI conjunction analysis showed brain preservation with PA and volume loss with increased BMI in overlapping brain regions. In one of the largest voxel-based cross-sectional studies to date, PA and lower BMI may be beneficial to the brain across the spectrum of aging and neurodegeneration.

Indexed as

Body Mass IndexAgedAged, 80 and overAgingAlzheimer DiseaseAtrophyBiomarkersBrainCognitive DysfunctionCross-Sectional StudiesDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMaleMotor ActivityBiomarkersAlzheimer'sBody mass indexPhysical activityTensor-based morphometry

Identifiers

PMID25248607
PMCPMC4303036
OpenAlexW2077119719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.