ArticleEuropean journal of human genetics : EJHG2015
Points to consider for prioritizing clinical genetic testing services: a European consensus process oriented at accountability for reasonableness.
Article in European journal of human genetics : EJHG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Patient harms during delayed access to clinical genetics services. A systematic literature review and synthesis without meta-analysis (SWiM).European journal of human genetics : EJHG · 2026Review
- Unbiased inference for echocardiogram urgency prediction using double machine learning.PloS one · 2026Article
- Monogenic Common Variable Immunodeficiency (Mo-CVID) Score for Optimizing the Genetic Diagnosis in Pediatric CVID Cohort.European journal of immunology · 2025Article
- Navigating Genetic Testing in Nephrology: Options and Decision-Making Strategies.Kidney international reports · 2025Review
- Physician and informal care use explained by the Pediatric Quality of Life Inventory (PedsQL) in children with suspected genetic disorders.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Nigerian parents' perspectives on genetic testing in their children with genetic eye diseases.Journal of community genetics · 2023Article
- Survey of Professionals of the European Public Health Association (EUPHA) towards Direct-to-Consumer Genetic Testing.European journal of public health · 2023Article
- A New Tool for Determining and Monitoring Public Healthcare Systems.Healthcare (Basel, Switzerland) · 2022Article
- Neonatal Screening in Europe Revisited: An ISNS Perspective on the Current State and Developments Since 2010.International journal of neonatal screening · 2021Article
- Opportunistic genomic screening. Recommendations of the European Society of Human Genetics.European journal of human genetics : EJHG · 2021Article
- Clinical management, ethics and informed consent related to multi-gene panel-based high throughput sequencing testing for platelet disorders: Communication from the SSC of the ISTH.Journal of thrombosis and haemostasis : JTH · 2020Article
- Case Report: Hypertriglyceridemia and Premature Atherosclerosis in a Patient With Apolipoprotein E Gene εFrontiers in cardiovascular medicine · 2020Article
- Genomics knowledge and attitudes among European public health professionals: Results of a cross-sectional survey.PloS one · 2020Article
- Envisioning Implementation of a Personalized Approach in Breast Cancer Screening Programs: Stakeholder Perspectives.Healthcare policy = Politiques de sante · 2019Article
- Towards establishing consistency in triage in a tertiary specialty.European journal of human genetics : EJHG · 2019Article
- The challenges of the expanded availability of genomic information: an agenda-setting paper.Journal of community genetics · 2018Article
- Human Dignity as Leading Principle in Public Health Ethics: A Multi-Case Analysis of 21st Century German Health Policy Decisions.International journal of health policy and management · 2018Article
- Barriers and Facilitating Factors for Implementation of Genetic Services: A Public Health Perspective.Frontiers in public health · 2017Article
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the cost constraints of the European health-care systems, criteria are needed to decide which genetic services to fund from the public budgets, if not all can be covered. To ensure that high-priority services are available equitably within and across the European countries, a shared set of prioritization criteria would be desirable. A decision process following the accountability for reasonableness framework was undertaken, including a multidisciplinary EuroGentest/PPPC-ESHG workshop to develop shared prioritization criteria. Resources are currently too limited to fund all the beneficial genetic testing services available in the next decade. Ethically and economically reflected prioritization criteria are needed. Prioritization should be based on considerations of medical benefit, health need and costs. Medical benefit includes evidence of benefit in terms of clinical benefit, benefit of information for important life decisions, benefit for other people apart from the person tested and the patient-specific likelihood of being affected by the condition tested for. It may be subject to a finite time window. Health need includes the severity of the condition tested for and its progression at the time of testing. Further discussion and better evidence is needed before clearly defined recommendations can be made or a prioritization algorithm proposed. To our knowledge, this is the first time a clinical society has initiated a decision process about health-care prioritization on a European level, following the principles of accountability for reasonableness. We provide points to consider to stimulate this debate across the EU and to serve as a reference for improving patient management.
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