ArticleEuropean journal of pediatrics2015
Arterial stiffness is increased in asthmatic children.
Article in European journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02853747 (Exercise and Arterial Modulation in Youth), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise and Arterial Modulation in Youth
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Asthma and high-intensity interval training have no effect on clustered cardiometabolic risk or arterial stiffness in adolescents.European journal of applied physiology · 2021Trial
- Cardiovascular Events in Patients with Severe Asthma-A Retrospective Study of Two Cohorts: Asthma Type T2 Treated with Biologics and Non-Type T2.Journal of clinical medicine · 2024Article
- Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study.Biomedicines · 2022Article
- Allergic asthma is a risk factor for human cardiovascular diseases.Nature cardiovascular research · 2022Review
- Neuroimaging and biomarker evidence of neurodegeneration in asthma.The Journal of allergy and clinical immunology · 2022Article
- The association of allergic asthma and carotid intima-media thickness in adolescence: data of the prospective early vascular ageing (EVA)-Tyrol cohort study.BMC cardiovascular disorders · 2022Article
- Updated and revised normal values of aortic pulse wave velocity in children and adolescents aged 3-18 years.Journal of human hypertension · 2021Article
- Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner.PloS one · 2019Article
- History of Asthma From Childhood and Arterial Stiffness in Asymptomatic Young Adults: The Bogalusa Heart Study.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Is there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?European journal of pediatrics · 2018Article
- Brief Report: Physical Activity, Body Mass Index and Arterial Stiffness in Children with Autism Spectrum Disorder: Preliminary Findings.Journal of autism and developmental disorders · 2018Article
- Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multiethnic cohort.Journal of hypertension · 2017Article
- Feasibility and characteristics of arterial stiffness measurement in preschool children.European journal of preventive cardiology · 2017Article
- Age and cigarette smoking modulate the relationship between pulmonary function and arterial stiffness in heart failure patients.Medicine · 2017Observational
- Arterial Stiffness, Distensibility, and Strain in Asthmatic Children.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- The effects of treatment in patients with childhood asthma on the elastic properties of the aorta.Cardiovascular journal of AfricaArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledAltered arterial stiffness is a recognized risk factor of poor cardiovascular health. Chronic inflammation may increase arterial stiffness. We tested whether arterial stiffness is increased children with asthma, a chronic disease characterized by fluctuating airway and systemic inflammation. Arterial stiffness, expressed as carotid-femoral pulse wave velocity (PWVcf), was measured in 37 mild-to-moderate asthmatic children: 11 girls, median (range) age 11.1 years (6-15). PWVcf in asthma was compared to PWVcf in 65 healthy controls matched for age, height, and gender previously studied in Germany and was correlated with airway inflammation and obstruction. PWVcf was higher in asthmatic children compared to controls: PWVcf median (interquartile range) was 4.7 m/s (4.5-4.9) vs. 4.3 m/s (4.1-4.7), p < 0.0001. In asthmatic children, PWVcf was inversely associated (r (2) = 0.20, p = 0.004) with forced expiratory volume in 1 s (FEV1). This association remained significant after adjusting for possible confounders including body mass index, blood pressure, steroid use, and FeNO.
conclusionArterial stiffness is increased in children with mild-to-moderate asthma. The association between impaired lung function and increased arterial stiffness suggests that severity of disease translates into detrimental effects on the cardiovascular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.