ArticleIEEE transactions on medical imaging2015
Quantitative susceptibility mapping by inversion of a perturbation field model: correlation with brain iron in normal aging.
Article in IEEE transactions on medical imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Iron load in the normal aging brain measured with QSM andFrontiers in neuroimaging · 2024Article
- Review
- Article
- Comparison of quantitative susceptibility mapping methods on evaluating radiation-induced cerebral microbleeds and basal ganglia at 3T and 7T.NMR in biomedicine · 2022Article
- QSMGAN: Improved Quantitative Susceptibility Mapping using 3D Generative Adversarial Networks with increased receptive field.NeuroImage · 2020Article
- Distribution of brain iron accrual in adolescence: Evidence from cross-sectional and longitudinal analysis.Human brain mapping · 2019Article
- Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.Cell & bioscience · 2018Article
- Significance andFrontiers in immunology · 2018Review
- Preconditioned total field inversion (TFI) method for quantitative susceptibility mapping.Magnetic resonance in medicine · 2017Article
- Exploring the origins of echo-time-dependent quantitative susceptibility mapping (QSM) measurements in healthy tissue and cerebral microbleeds.NeuroImage · 2017Article
- Stability of R2* and quantitative susceptibility mapping of the brain tissue in a large scale multi-center study.Scientific reports · 2017Article
- In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Appraising the Role of Iron in Brain Aging and Cognition: Promises and Limitations of MRI Methods.Neuropsychology review · 2015Review
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Authors and funding
6 authors.
Funding
Abstract
There is increasing evidence that iron deposition occurs in specific regions of the brain in normal aging and neurodegenerative disorders such as Parkinson's, Huntington's, and Alzheimer's disease. Iron deposition changes the magnetic susceptibility of tissue, which alters the MR signal phase, and allows estimation of susceptibility differences using quantitative susceptibility mapping (QSM). We present a method for quantifying susceptibility by inversion of a perturbation model, or "QSIP." The perturbation model relates phase to susceptibility using a kernel calculated in the spatial domain, in contrast to previous Fourier-based techniques. A tissue/air susceptibility atlas is used to estimate B0 inhomogeneity. QSIP estimates in young and elderly subjects are compared to postmortem iron estimates, maps of the Field-Dependent Relaxation Rate Increase, and the L1-QSM method. Results for both groups showed excellent agreement with published postmortem data and in vivo FDRI: statistically significant Spearman correlations ranging from Rho=0.905 to Rho=1.00 were obtained. QSIP also showed improvement over FDRI and L1-QSM: reduced variance in susceptibility estimates and statistically significant group differences were detected in striatal and brainstem nuclei, consistent with age-dependent iron accumulation in these regions.
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