ArticlePloS one2014
A H2S-Nampt dependent energetic circuit is critical to survival and cytoprotection from damage in cancer cells.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- A mitochondria-targeted chemiluminescent probe for detection of hydrogen sulfide in cancer cells, human serum andRSC chemical biology · 2023Article
- Sol-Gel Dipping Devices for HSensors (Basel, Switzerland) · 2023Article
- The Role of Hydrogen Sulfide in the Development and Progression of Lung Cancer.Molecules (Basel, Switzerland) · 2022Review
- Emerging roles of cystathionine β-synthase in various forms of cancer.Redox biology · 2022Review
- Paper-Strip-Based Sensors for HSensors (Basel, Switzerland) · 2022Article
- Review
- Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential.Journal of advanced research · 2021Review
- NADSignal transduction and targeted therapy · 2021Review
- Review
- Subcellular compartmentalization of NADPharmacology & therapeutics · 2019Review
- Exogenous HAmerican journal of physiology. Endocrinology and metabolism · 2019Article
- Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies.Oxidative medicine and cellular longevity · 2019Review
- The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations.DNA repair · 2019Article
- Cystathione β-Synthase Is Increased in Thyroid Malignancies.Anticancer research · 2018Article
- Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae.Anticancer research · 2018Article
- Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma.Anticancer research · 2017Article
- Regulation and role of endogenously produced hydrogen sulfide in angiogenesis.Pharmacological research · 2016Review
- Organelle-Targeted H2S Probes Enable Visualization of the Subcellular Distribution of H2S Donors.Analytical chemistry · 2016Article
- Gasotransmitters in cancer: from pathophysiology to experimental therapy.Nature reviews. Drug discovery · 2016Review
- Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner.PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently demonstrated that cancer cells that recover from damage exhibit increased aerobic glycolysis, however, the molecular mechanism by which cancer cells survive the damage and show increased aerobic glycolysis remains unknown. Here, we demonstrate that diverse cancer cells that survive hypoxic or oxidative damage show rapid cell proliferation, and develop tolerance to damage associated with increased production of hydrogen sulfide (H2S) which drives up-regulation of nicotinamide phosphoribosyltransferase (Nampt). Consistent with existence of a H2S-Nampt energetic circuit, in damage recovered cancer cells, H2S, Nampt and ATP production exhibit a significant correlation. Moreover, the treatment of cancer cells with H2S donor, NaHS, coordinately increases Nampt and ATP levels, and protects cells from drug induced damage. Inhibition of cystathionine beta synthase (CBS) or cystathionase (CTH), enzymes which drive generation of H2S, decreases Nampt production while suppression of Nampt pathway by FK866, decreases H2S and ATP levels. Damage recovered cells isolated from tumors grown subcutaneously in athymic mice also show increased production of H2S, Nampt and ATP levels, associated with increased glycolysis and rapid proliferation. Together, these data show that upon recovery from potential lethal damage, H2S-Nampt directs energy expenditure and aerobic glycolysis in cancer cells, leads to their exponential growth, and causes a high degree of tolerance to damage. Identification of H2S-Nampt as a pathway responsible for induction of damage tolerance in cancer cells may underlie resistance to therapy and offers the opportunity to target this pathway as a means in treatment of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.